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/lp/karger/inhibition-by-derivatives-of-phloretin-of-anaphylactic-histamine-jnPCi9rIQ4
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- Publisher
- Karger
- Copyright
- © 1975 S. Karger AG, Basel
- ISSN
- 1018-2438
- eISSN
- 1423-0097
- DOI
- 10.1159/000231298
- Publisher site
- See Article on Publisher Site
Abstract
Derivatives of phloretin (25–1,000 μg/ml) among them polyphloretin phosphate (PPP), inhibited in a dose-dependent manner anaphylactic (birch pollen or horse dander) histamine release from human lung tissue passively sensitized with reaginic serum. Pretreatment with PPP of lung tissue sensitized both to birch pollen and horse dander counteracted to a similar extent the release of histamine induced by either allergen administered in sequence. The phloretin derivatives also antagonized the constrictor action of prostaglandin F<sub>2α</sub> on isolated human bronchi at concentrations which did not impair the responses to histamine. The low and high molecular weight derivatives of phloretin were comparably active on a weight basis in both experimental systems.
Journal
International Archives of Allergy and Immunology – Karger
Published: Jan 1, 1975