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Induction of Tumor Necrosis Factor in Human Peripheral-Blood Mononuclear Cells by Proteolytic Enzymes

Induction of Tumor Necrosis Factor in Human Peripheral-Blood Mononuclear Cells by Proteolytic... We could demonstrate that polyenzyme preparations as well as bromelain and papain stimulate the production of tumor necrosis factor-α in human peripheral-blood mononuclear cell cultures in a time-dependent manner. We give evidence that immunomodulation and especially the release of cytokines may contribute to the therapeutic effect of these preparations. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Oncology Karger

Induction of Tumor Necrosis Factor in Human Peripheral-Blood Mononuclear Cells by Proteolytic Enzymes

Desser, Lucia; Rehberger, Alexander
Oncology , Volume 47 (6): 3 – Jan 1, 1990
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Publisher
Karger
Copyright
© 1990 S. Karger AG, Basel
ISSN
0030-2414
eISSN
1423-0232
DOI
10.1159/000226875
Publisher site
See Article on Publisher Site

Abstract

We could demonstrate that polyenzyme preparations as well as bromelain and papain stimulate the production of tumor necrosis factor-α in human peripheral-blood mononuclear cell cultures in a time-dependent manner. We give evidence that immunomodulation and especially the release of cytokines may contribute to the therapeutic effect of these preparations.

Journal

Oncology – Karger

Published: Jan 1, 1990

Keywords: Peripheral-blood mononuclear cells; Proteolytic enzymes; Tumor necrosis factor

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