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Immunocytochemical Staining of Kupffer and Endothelial Cells in Fine Needle Aspiration Cytology of Hepatocellular Carcinoma

Immunocytochemical Staining of Kupffer and Endothelial Cells in Fine Needle Aspiration Cytology... Acta Cytologica Immunocytochemical Staining of Kupffer and Endothelial Cells in Fine Needle Aspiration Cytology of Hepatocellular Carcinoma Sheida Sharifi, M.D., Ph.D., Jihad Hayek, M.D., Urmila Khettry, M.B., B.S., and Imad Nasser, M.D. OBJECTIVE: To evaluate the significance of the presence Factor VIII and vimentin, while 22% of cases of AC of Kupffer and endothelial cells in distinguishing hepato- showed immunostaining for both Factor VIII and vi- cellular carcinoma (HCC) mentin (P = .18). and adenocarcinoma (AC) CONCLUSION: Immuno- on cytologic smears. cytochemical identification of A thorough cytomorphologic analysis STUDY DESIGN: Fine nee- endothelial cells using Factor in conjunction with careful clinical dle aspiration biopsies VIII may have important di- (FNABs) from 43 cases, 21 agnostic value in separating correlation is essential to rendering HCC and 22 AC (8 primary HCC from adenocarcinomas a correct diagnosis in the evaluation and 14 metastatic), were im- in liver FNABs. The pres- munostained for Factor VIII of liver FNAB. ence of Kupffer cells labeled and vimentin as markers for with vimentin has no diag- endothelial cells and Kupffer nostic significance in FNAB cells, respectively. Cytologic diagnosis was verified by of these tumors. (Acta Cytol 2000;44:7–12) histologic and/or clinical follow-up. RESULTS: Eighteen of the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Cytologica Karger

Immunocytochemical Staining of Kupffer and Endothelial Cells in Fine Needle Aspiration Cytology of Hepatocellular Carcinoma

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References (23)

Publisher
Karger
Copyright
© 2011 S. Karger AG, Basel
ISSN
0001-5547
eISSN
1938-2650
DOI
10.1159/000326216
Publisher site
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Abstract

Acta Cytologica Immunocytochemical Staining of Kupffer and Endothelial Cells in Fine Needle Aspiration Cytology of Hepatocellular Carcinoma Sheida Sharifi, M.D., Ph.D., Jihad Hayek, M.D., Urmila Khettry, M.B., B.S., and Imad Nasser, M.D. OBJECTIVE: To evaluate the significance of the presence Factor VIII and vimentin, while 22% of cases of AC of Kupffer and endothelial cells in distinguishing hepato- showed immunostaining for both Factor VIII and vi- cellular carcinoma (HCC) mentin (P = .18). and adenocarcinoma (AC) CONCLUSION: Immuno- on cytologic smears. cytochemical identification of A thorough cytomorphologic analysis STUDY DESIGN: Fine nee- endothelial cells using Factor in conjunction with careful clinical dle aspiration biopsies VIII may have important di- (FNABs) from 43 cases, 21 agnostic value in separating correlation is essential to rendering HCC and 22 AC (8 primary HCC from adenocarcinomas a correct diagnosis in the evaluation and 14 metastatic), were im- in liver FNABs. The pres- munostained for Factor VIII of liver FNAB. ence of Kupffer cells labeled and vimentin as markers for with vimentin has no diag- endothelial cells and Kupffer nostic significance in FNAB cells, respectively. Cytologic diagnosis was verified by of these tumors. (Acta Cytol 2000;44:7–12) histologic and/or clinical follow-up. RESULTS: Eighteen of the

Journal

Acta Cytologica – Karger

Published: Jan 1, 2011

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