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Immunocytochemical Observations of Corticotropin-Releasing-Factor-Containing Neurons in the Rat Hypothalamus with Special Reference to Neuronal Communication

Immunocytochemical Observations of Corticotropin-Releasing-Factor-Containing Neurons in the Rat... Synapses between neurons with corticotropin-releasing-factor-(CRF)-like immunoreactivities and other immunonegative neurons in the hypothalamus of colchicine-treated rats, especially in the paraventricular nucleus (PVN) and the supraoptic nucleus (SON) were observed by immunocytochemistry using CRF antiserum. The immunoreactive nerve cell bodies and fibers were numerous in both the PVN and the SON. The CRF-containing neurons had synaptic contacts with immunonegative axon terminals containing a large number of clear synaptic vesicles alone or combined with a few dense-cored vesicles. We also found CRF-like immunoreactive axon terminals making synaptic contacts with other immunonegative neuronal cell bodies and fibers. And since some postsynaptic immunonegative neurons contained many large neurosecretory granules, they are considered to be magnocellular neurosecretory cells. These findings suggest that CRF functions as a neurotransmitter and/or modulator in addition to its function as a hormone. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cells Tissues Organs Karger

Immunocytochemical Observations of Corticotropin-Releasing-Factor-Containing Neurons in the Rat Hypothalamus with Special Reference to Neuronal Communication

Shioda, S.; Nakai, Y.; Kitazawa, S.; Sunayama, H.
Cells Tissues Organs , Volume 124 (1-2): 7 – Jan 1, 1985
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Publisher
Karger
Copyright
© 1985 S. Karger AG, Basel
ISSN
1422-6405
eISSN
1422-6421
DOI
10.1159/000146097
Publisher site
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Abstract

Synapses between neurons with corticotropin-releasing-factor-(CRF)-like immunoreactivities and other immunonegative neurons in the hypothalamus of colchicine-treated rats, especially in the paraventricular nucleus (PVN) and the supraoptic nucleus (SON) were observed by immunocytochemistry using CRF antiserum. The immunoreactive nerve cell bodies and fibers were numerous in both the PVN and the SON. The CRF-containing neurons had synaptic contacts with immunonegative axon terminals containing a large number of clear synaptic vesicles alone or combined with a few dense-cored vesicles. We also found CRF-like immunoreactive axon terminals making synaptic contacts with other immunonegative neuronal cell bodies and fibers. And since some postsynaptic immunonegative neurons contained many large neurosecretory granules, they are considered to be magnocellular neurosecretory cells. These findings suggest that CRF functions as a neurotransmitter and/or modulator in addition to its function as a hormone.

Journal

Cells Tissues Organs – Karger

Published: Jan 1, 1985

Keywords: Rat; Hypothalamus; Corticotropin-releasing factor; Immunocytochemistry; Synapse

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