Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/karger/how-age-changes-the-content-of-neuroendocrine-peptides-in-the-murine-TgxHsYeWc5
References (20)
-
Low levels of colonic somatostatin and galanin in patients with colon carcinoma -
P. Ruszniewski, T. Lehy, F. Reyl-Desmars, Sylvie Roux, M. Lewin (1993)
Octreotide (SMS 201–995) inhibits the growth of colon peritoneal carcinomatosis in BDIX ratsRegulatory Peptides, 43
-
M. O'dorisio (1986)
Neuropeptides and gastrointestinal immunity.The American journal of medicine, 81 6B
-
D. Dy, R. Whitehead, D. Morris (1992)
SMS 201.995 inhibits in vitro and in vivo growth of human colon cancer.Cancer research, 52 4
-
J. Haseman, D. Hoel (1979)
Statistical design of toxicity assays: role of genetic structure of test animal population.Journal of toxicology and environmental health, 5 1
-
Jill Smith, T. Solomon (1988)
Effects of gastrin, proglumide, and somatostatin on growth of human colon cancer.Gastroenterology, 95 6
-
(1996)
Somatostin and cancer -
A. Paolo, G. Bocci, F. Innocenti, C. Agen, D. Nardini, R. Danesi, M. Tacca (1995)
Inhibitory effect of the somatostatin analogue SMS 201-995 and cytokines on the proliferation of human colon adenocarcinoma cell lines.Pharmacological research, 32 3
-
H. Iishi, M. Tatsuta, M. Baba, H. Uehara, H. Yano, A. Nakaizumi (1995)
Chemoprevention by galanin against colon carcinogenesis induced by azoxymethane in wistar ratsInternational Journal of Cancer, 61
-
J. Bannister, L. Abouzekry, N. Read (1987)
Effect of aging on anorectal function.Gut, 28
-
M. El-Salhy, J. Mahdavi, Ö. Norrgård (1998)
Colonic endocrine cells in patients with carcinoma of the colonEuropean Journal of Gastroenterology & Hepatology, 10
-
(1994)
Regulation of gastrointestinal mucosal growth; in Johnson LR (ed): Physiology of the Grastrointerstinal Tract -
(1979)
Longevity studies in NMRI mice -
G. Stewart, Jennie Connor, J. Lawson, A. Preketes, J. King, D. Morris (1995)
Octreotide reduces the kinetic index, proliferating cell nuclear antigen–maximum proliferative index, in patients with colorectal cancerCancer, 76
-
J. Mcdougal, M. Miller, T. Burks, D. Kreulen (1984)
Age-related changes in colonic function in rats.The American journal of physiology, 247 5 Pt 1
-
J. Johanson, A. Sonnenberg, T. Koch (1989)
Clinical epidemiology of chronic constipation.Journal of clinical gastroenterology, 11 5
-
(1990)
Postulated pathophysiological roles in motility; in Daniel E (ed): Neuropeptides Function in Gastrointestinal Tract -
R. Walford (1976)
When Is a Mouse “Old”?The Journal of Immunology
-
J. Hollis, D. Castell (1974)
Esophageal function in elderly man. A new look at "presbyesophagus".Annals of internal medicine, 80 3
-
M. Alonso, M. Galera, G. Reyes, R. Calabuig, A. Viñals, X. Ríus (1992)
Effects of pentagastrin and of the somatostatin analog (SMS 201-995) on growth of CT26 in vivo adenocarcinoma of the colon.Surgery, gynecology & obstetrics, 175 5
- Publisher
- Karger
- Copyright
- © 1998 S. Karger AG, Basel
- ISSN
- 0304-324X
- eISSN
- 1423-0003
- DOI
- 10.1159/000022050
- Publisher site
- See Article on Publisher Site
Abstract
Background: Motility disorders in the gastrointestinal tract increase with ageing, and colorectal carcinoma is a tumor of the middle-aged and elderly. Gastrointestinal secretion, absorption, motility, cell proliferation, local immune defense and blood flow are all regulated by the neuroendocrine peptides. It is conceivable that gastrointestinal disorders at an advanced age may be accompanied by changes in this regulatory system. Objective: To ascertain possible age-related changes in neuroendocrine peptides in a rodent animal model. Methods: The concentrations of various neuroendocrine peptides were determined by radioimmunoassays in tissue extracts from the antrum, duodenum and colon of mice in four different age groups: 1, 3, 12 and 24 months. The neuroendocrine peptides investigated were: secretin, gastric inhibitory polypeptide (GIP), gastrin, motilin, peptide YY (PYY), somatostatin, vasoactive intestinal polypeptide (VIP), substance P, neuropeptide Y (NPY), galanin and neurotensin. Results: Antrum: Concentrations of somatostatin, VIP and substance P decreased significantly in 1-month-old mice (but that of neurotensin increased) compared with 3-month-old mice. In 12-month-old and 24-month-old mice, concentrations of gastrin, somatostatin, VIP, substance P, NPY, galanin and neurotensin all decreased vis-à-vis 3-month-old mice. Duodenum: Whereas the levels of secretin, GIP and neurotensin increased, those of gastrin, motilin, somatostatin, VIP, substance P, NPY and galanin decreased in 1-month-old mice vis-à-vis 3-month-old mice. In both 12-month-old and 24-month-old mice, the concentrations of secretin and GIP increased, compared with those of 3-month-old mice. The levels of gastrin, motilin, somatostatin, VIP, NPY and galanin decreased in both 12-month-old and 24-month-old mice vis-à-vis 3-month-old mice. Substance P and neurotensin concentrations decreased in 12-month-old mice, but not in 24-month-old mice. Colon: In 1-month-old mice the levels of PYY, somatostatin, VIP, substance P and galanin decreased vis-à-vis 3-month-old mice. In 12-month-old mice, the concentrations of PYY, somatostatin, VIP, NPY, galanin and neurotensin decreased compared with those in 3-month-old mice. In 24-month-old mice, the VIP level decreased, whereas the substance P level increased. Conclusion: The changes in neuroendocrine peptides observed in the gastrointestinal tract of this murine animal model could be of some relevance for the increased gastrointestinal dysfunction in the elderly human. They may also be involved in the development of colorectal cancer.
Journal
Gerontology – Karger
Published: Feb 1, 1999
Keywords: Radioimmunoassay; Ageing; Colorectal carcinoma; Gastrointestinal tract; Mice; Motility; Neuroendocrine peptides