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/lp/karger/evidence-for-the-histamine-mediated-myotropic-effect-of-angiotensin-ii-m3f09ugLkE
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- Publisher
- Karger
- Copyright
- © 1979 S. Karger AG, Basel
- ISSN
- 0031-7012
- eISSN
- 1423-0313
- DOI
- 10.1159/000137264
- Publisher site
- See Article on Publisher Site
Abstract
Histamine H<sub>1</sub>-receptor antagonist mepyramine and H<sub>2</sub>-receptor antagonist metiamide, respectively diminished and potentiated angiotensin II (AII)-induced myotropic responses in the rabbit aortic strips. The responses of the octapeptide were also inhibited in the presence of histidine decarboxylase inhibitor, 2-hydroxy-5-carbomethoxybenzoxyamine and restored when subcontractile quantities of histamine are added to the inhibitor-containing medium. Inhibition of histamine degradation by aminoguanidine potentiates A II’s responses. These results are taken as evidences indicating AII-induced histamine synthesis in the test preparation.
Journal
Pharmacology – Karger
Published: Jan 1, 1979
Keywords: Rabbit aorta; Angiotensin II; Induced histamine