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Etude histologique de l’action du Propranolol sur l’appareil génital du rat mâle

Etude histologique de l’action du Propranolol sur l’appareil génital du rat mâle Increasing doses of propranolol were injected intraperitoneally to four series of adult male rats in order to study the effect of this β-blocking agent on various organs (testis, epididymis, prostate and seminal vesicle) and endocrine glands (adrenals, pancreas, thyroid, pituitary). Histological damage was observed only in testes: i.e., necrosis and desquamation of germinal cells in the seminiferous tubules associated with light arterial vasoconstriction. Pelviperitoneal fibrosis was observed as well. These lesions seem to be of pharmacological vascular origin and appear to occur in combination with an elective toxic effect of propranolol on the germinal cells. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cells Tissues Organs Karger

Etude histologique de l’action du Propranolol sur l’appareil génital du rat mâle

Cells Tissues Organs , Volume 109 (4): 9 – Jan 1, 1981

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Publisher
Karger
Copyright
© 1981 S. Karger AG, Basel
ISSN
1422-6405
eISSN
1422-6421
DOI
10.1159/000145401
Publisher site
See Article on Publisher Site

Abstract

Increasing doses of propranolol were injected intraperitoneally to four series of adult male rats in order to study the effect of this β-blocking agent on various organs (testis, epididymis, prostate and seminal vesicle) and endocrine glands (adrenals, pancreas, thyroid, pituitary). Histological damage was observed only in testes: i.e., necrosis and desquamation of germinal cells in the seminiferous tubules associated with light arterial vasoconstriction. Pelviperitoneal fibrosis was observed as well. These lesions seem to be of pharmacological vascular origin and appear to occur in combination with an elective toxic effect of propranolol on the germinal cells.

Journal

Cells Tissues OrgansKarger

Published: Jan 1, 1981

Keywords: Testis; Propranolol; Rat; Histology

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