Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/karger/electroencephalographic-studies-of-haloperidol-Pdu4utwEuZ
References
References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.
- Publisher
- Karger
- Copyright
- © 1968 S. Karger AG, Basel
- ISSN
- 0020-8272
- eISSN
- 2504-2580
- DOI
- 10.1159/000467926
- Publisher site
- See Article on Publisher Site
Abstract
1. Effects of haloperidol on EEG were examined in rabbits, curarizedand artificially respired. Twenty-five rabbits were used for studyingthe effect of acute administration and 25 rabbits for chronic administration.2. Haloperidol in doses of 1.5—4.0 mg/kg i.v. evoked two main changesin the EEG. Namely, a synchronization of cortical and subcorticalEEG patterns and a continuous desynchronized pattern in theolfactory bulb. In addition, the cortical EEG arousal reactions toclap and pain were blocked at 1.8 ± 0.8mg/kg and 2.9 ± 0.8 mg/kgrespectively. Hippocampal arousal reaction to these stimulations wasnot completely blocked.3. When more than 4.5 mg/kg was given, EEG activities of all the brainareas showed a continuous arousal pattern in 8 rabbits out of 15.4. There are two chief negative results. The chronic administration ofhaloperidol for 2—10 days did not significantly affect the per centtime distribution of arousal, mixed and resting patterns. Moreover,threshold voltages required to induce hippocampal seizure dischargesfollowing electrical stimulation of hippocampus were not significantlyraised with the acute administration of 1.5 mg/kg of haloperidol.
Journal
International Pharmacopsychiatry – Karger
Published: Jan 1, 2017