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Electroencephalographic Correlates of Periventricular White Matter Lesions in Probable Alzheimer’ Disease

Electroencephalographic Correlates of Periventricular White Matter Lesions in Probable Alzheimer’... We evaluated the relationship between periventricular white matter lesions (PWMLs) and EEG abnormalities in probable Alzheimer''s disease (AD). We visually analyzed the EEG of 27 probable AD patients with mild to moderate degree of cognitive impairment participating in a longitudinal study of dementia. Patients had both CT and MRI scans performed at baseline examination, which also included an EEG. PWMLs were rated in CT and MRI films using a semiquantitative method. The EEGs were classified according to the Mayo Clinic Classification System. Abnormal EEGs correlated with PWMLs rating scores were detected on CT, but not on MRI. These data suggest that the presence of PWMLs contribute to the abnormal EEGs observed in AD patients, and that white matter abnormalities in CT correlate better with both the clinical findings and EEG than does the more sensitive but less specific MRI. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Dementia and Geriatric Cognitive Disorders Karger

Electroencephalographic Correlates of Periventricular White Matter Lesions in Probable Alzheimer’ Disease

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Publisher
Karger
Copyright
© 1995 S. Karger AG, Basel
ISSN
1420-8008
eISSN
1421-9824
DOI
10.1159/000106968
Publisher site
See Article on Publisher Site

Abstract

We evaluated the relationship between periventricular white matter lesions (PWMLs) and EEG abnormalities in probable Alzheimer''s disease (AD). We visually analyzed the EEG of 27 probable AD patients with mild to moderate degree of cognitive impairment participating in a longitudinal study of dementia. Patients had both CT and MRI scans performed at baseline examination, which also included an EEG. PWMLs were rated in CT and MRI films using a semiquantitative method. The EEGs were classified according to the Mayo Clinic Classification System. Abnormal EEGs correlated with PWMLs rating scores were detected on CT, but not on MRI. These data suggest that the presence of PWMLs contribute to the abnormal EEGs observed in AD patients, and that white matter abnormalities in CT correlate better with both the clinical findings and EEG than does the more sensitive but less specific MRI.

Journal

Dementia and Geriatric Cognitive Disorders – Karger

Published: Jan 1, 1995

Keywords: EEG; Dementia; White matter lesions; Alzheimer’ disease

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