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Effects of Papaverine and Prostaglandin E(1), on Corpus cavernosum Smooth Muscle of Arteriogenically and Diabetically Impotent Men

Effects of Papaverine and Prostaglandin E(1), on Corpus cavernosum Smooth Muscle of... Relaxant effect of prostaglandin E(1) (PGE(1)) and papaverine (PAP) were measuredin strips of corpus cavernosum smooth muscle taken from a healthycontrol group of men (A; n = 5), from arteriogenically impotent men (B; n = 6)and from additionally diabetic impotent men (C; n = 5) with venous leakage.Maximal relaxant effect was achieved with PAP at a mean of 10~4 mol/1 andPGE(1) at a mean of 5.8 x 10^-6 mol/l. PAP induced complete relaxation in allstrips. There was no difference in relaxant effects between groups. Relaxanteffect was less pronounced and depended significantly on etiology: penylephrine-induced tension was reduced by 76± 8% (A), 54± 14% (B) and 23±18% (C), respectively. In conclusion, our data suggest degradation of PGE(1)receptors depending on the cause of erectile dysfunction. Furthermore, relaxantcapacity of cavernous smooth muscle per se seems not to be impaired inimpotence. Therefore, pathophysiology of venous leakage cannot sufficientlybe explained by a lack of relaxation. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Urology Karger

Effects of Papaverine and Prostaglandin E(1), on Corpus cavernosum Smooth Muscle of Arteriogenically and Diabetically Impotent Men

Knispel, H.H.; Goessl, C.; Beckmann, R.
European Urology , Volume 26 (1): 5 – Jan 1, 2017
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Publisher
Karger
Copyright
© 1994 S. Karger AG, Basel
ISSN
0302-2838
eISSN
1873-7560
DOI
10.1159/000475339
Publisher site
See Article on Publisher Site

Abstract

Relaxant effect of prostaglandin E(1) (PGE(1)) and papaverine (PAP) were measuredin strips of corpus cavernosum smooth muscle taken from a healthycontrol group of men (A; n = 5), from arteriogenically impotent men (B; n = 6)and from additionally diabetic impotent men (C; n = 5) with venous leakage.Maximal relaxant effect was achieved with PAP at a mean of 10~4 mol/1 andPGE(1) at a mean of 5.8 x 10^-6 mol/l. PAP induced complete relaxation in allstrips. There was no difference in relaxant effects between groups. Relaxanteffect was less pronounced and depended significantly on etiology: penylephrine-induced tension was reduced by 76± 8% (A), 54± 14% (B) and 23±18% (C), respectively. In conclusion, our data suggest degradation of PGE(1)receptors depending on the cause of erectile dysfunction. Furthermore, relaxantcapacity of cavernous smooth muscle per se seems not to be impaired inimpotence. Therefore, pathophysiology of venous leakage cannot sufficientlybe explained by a lack of relaxation.

Journal

European Urology – Karger

Published: Jan 1, 2017

Keywords: Erection; Impotence; Papaverine; Prostaglandin E(1); Relaxation; Smooth muscle

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