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/lp/karger/effect-of-reticuloendothelial-stimulators-on-the-tissue-changes-and-RNcRftnHoX
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- Publisher
- Karger
- Copyright
- © 1976 S. Karger AG, Basel
- ISSN
- 0250-6807
- eISSN
- 1421-9697
- DOI
- 10.1159/000175691
- Publisher site
- See Article on Publisher Site
Abstract
Administration of histamine phosphate or glycerol trioleate (RE stimulators) to cholesterol-fed rabbits induced identical pattern of changes in cholesterol, phospholipid and triglyceride levels of the blood. However, the incidence of atheroma index in aorta and coronary arteries were significantly higher in histamine-treated and glycerol-trioleate-treated animals compared to cholesterol-fed controls. The rise in these indices appeared to be only partly related to increase in serum β-liρoproteins but mostly due to increased permeability of the endothelium and internal elastic lamina probably caused by histamine phosphate and glycerol trioleate resulted in greater degree of atheromatous lesions in those groups.
Journal
Annals of Nutrition and Metabolism – Karger
Published: Jan 1, 1976
Keywords: Rabbits; Experimental atheroma; Reticuloendothelial stimulators