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Effect of Daunomycin on Myocardial Contractility and on the Action of β-Methyldigoxin

Effect of Daunomycin on Myocardial Contractility and on the Action of β-Methyldigoxin In isolated electrically driven guinea pig left atria daunomycin at concentrations of 50–200 μg/ml reduced the contraction. In the presence of daunomycin the positive inotropic effect of β-methyldigoxin was reduced and, at higher concentration of daunomycin, contractility was inhibited. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pharmacology Karger

Effect of Daunomycin on Myocardial Contractility and on the Action of β-Methyldigoxin

Bossa, R.; Galatulas, I.; Spiti, R.
Pharmacology , Volume 21 (6): 3 – Jan 1, 1980
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Publisher
Karger
Copyright
© 1980 S. Karger AG, Basel
ISSN
0031-7012
eISSN
1423-0313
DOI
10.1159/000137460
Publisher site
See Article on Publisher Site

Abstract

In isolated electrically driven guinea pig left atria daunomycin at concentrations of 50–200 μg/ml reduced the contraction. In the presence of daunomycin the positive inotropic effect of β-methyldigoxin was reduced and, at higher concentration of daunomycin, contractility was inhibited.

Journal

Pharmacology – Karger

Published: Jan 1, 1980

Keywords: β-Methyldigoxin; Guinea pig atrium; Daunomycin

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