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Effect of corticotropin, steroidogenic inhibitors and hypophysectomy on the nuclear volumes of fasciculata cells in the rat adrenal cortex

Effect of corticotropin, steroidogenic inhibitors and hypophysectomy on the nuclear volumes of... The purpose of this investigation was to measure quantitatively nuclear volumes in outer fasciculata cells in adrenal glands of rats subjected to chronic stimulation of steroido-genesis by ACTH, or to chronic inhibition of functional activity by hypophysectomy or by injection of the steroidogenic inhibitors, U-8113 (p-aminophenyl butanone) and SU-4885 (metopirone). Nuclear volumes, after a recovery period from those effects, were also measured. Chronic daily administrations of ACTH for 7, 14, and 30 days led to a progressive, statistically significant increase in nuclear volumes of fasciculata cells. These changes were found to have been reversed 14 days after discontinuation of hormone treatment. Hypophysectomy resulted in a significant decrease in nuclear volumes. The steroidogenic inhibitors SU-4885 and U-8113 had a biphasic effect on the nuclear volumes with an early decrease and subsequent increase to normal values. Since a decrease in nuclear volumes in the adrenal glands of inhibitor-treated subjects occurred in the presence of cellular hypertrophy and a significant increase in adrenal weights, it is concluded that changes in nuclear volumes can be positively correlated with the secretory activity of the cell rather than with the sizes of cells or glands. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cells Tissues Organs Karger

Effect of corticotropin, steroidogenic inhibitors and hypophysectomy on the nuclear volumes of fasciculata cells in the rat adrenal cortex

Sharawy, M.; Penney, David P.
Cells Tissues Organs , Volume 98 (4): 7 – Jan 1, 1977
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Publisher
Karger
Copyright
© 1977 S. Karger AG, Basel
ISSN
1422-6405
eISSN
1422-6421
DOI
10.1159/000144821
Publisher site
See Article on Publisher Site

Abstract

The purpose of this investigation was to measure quantitatively nuclear volumes in outer fasciculata cells in adrenal glands of rats subjected to chronic stimulation of steroido-genesis by ACTH, or to chronic inhibition of functional activity by hypophysectomy or by injection of the steroidogenic inhibitors, U-8113 (p-aminophenyl butanone) and SU-4885 (metopirone). Nuclear volumes, after a recovery period from those effects, were also measured. Chronic daily administrations of ACTH for 7, 14, and 30 days led to a progressive, statistically significant increase in nuclear volumes of fasciculata cells. These changes were found to have been reversed 14 days after discontinuation of hormone treatment. Hypophysectomy resulted in a significant decrease in nuclear volumes. The steroidogenic inhibitors SU-4885 and U-8113 had a biphasic effect on the nuclear volumes with an early decrease and subsequent increase to normal values. Since a decrease in nuclear volumes in the adrenal glands of inhibitor-treated subjects occurred in the presence of cellular hypertrophy and a significant increase in adrenal weights, it is concluded that changes in nuclear volumes can be positively correlated with the secretory activity of the cell rather than with the sizes of cells or glands.

Journal

Cells Tissues Organs – Karger

Published: Jan 1, 1977

Keywords: Adrenal cortex; Steroidogenic inhibitors; Nuclear volumes; ACTH

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