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Differences between Alkali Resistant Haemoglobin Fractions of Cooley’s Anaemia, of Fetal Blood and of Sickle Cell Anaemia

Differences between Alkali Resistant Haemoglobin Fractions of Cooley’s Anaemia, of Fetal Blood... Angelopoulos, B . a n d K o u re p i, M .: A cta h a c m a t. 24: 281—283 (1960). From the Haem atology L aboratory o f th e Evangelismos H ospital, Athens (D ir.: Dr. M . K o u r e p i) Differences between Alkali Resistant Haemoglobin Fractions of Cooley’s Anaemia, of Fetal Blood and of Sickle Cell Anaemia* By B. A n g e l o p o u l o s a n d M. K o u r e p i An alkali resistant haemoglobin having all properties of normal fetal haemoglobin has been described in C o o l e y ’s anaemia and in sickle cell anaemia. This haemoglobin and fetal haemoglobin react identically to dénaturation in aqueous alkaline solutions, have the same migration on paper electrophoresis in an alkaline medium and show the same crystallization, solubility and ultra­ violet absorption. The majority of the authors admit that the alkali resistant haemoglobin fractions of C o o l e y ’s and sickle cell anaemia are identical with fetal haemoglobin. Other observations, however, maintain differences exist among the alkaline resistant haemoglobin fractions. Thus S in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Haematologica Karger

Differences between Alkali Resistant Haemoglobin Fractions of Cooley’s Anaemia, of Fetal Blood and of Sickle Cell Anaemia

Angelopoulos, B.; Kourepi, M.
Acta Haematologica , Volume 24 (5): 3 – Jan 1, 2009
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Publisher
Karger
Copyright
© 1960 S. Karger AG, Basel
ISSN
0001-5792
eISSN
1421-9662
DOI
10.1159/000206472
Publisher site
See Article on Publisher Site

Abstract

Angelopoulos, B . a n d K o u re p i, M .: A cta h a c m a t. 24: 281—283 (1960). From the Haem atology L aboratory o f th e Evangelismos H ospital, Athens (D ir.: Dr. M . K o u r e p i) Differences between Alkali Resistant Haemoglobin Fractions of Cooley’s Anaemia, of Fetal Blood and of Sickle Cell Anaemia* By B. A n g e l o p o u l o s a n d M. K o u r e p i An alkali resistant haemoglobin having all properties of normal fetal haemoglobin has been described in C o o l e y ’s anaemia and in sickle cell anaemia. This haemoglobin and fetal haemoglobin react identically to dénaturation in aqueous alkaline solutions, have the same migration on paper electrophoresis in an alkaline medium and show the same crystallization, solubility and ultra­ violet absorption. The majority of the authors admit that the alkali resistant haemoglobin fractions of C o o l e y ’s and sickle cell anaemia are identical with fetal haemoglobin. Other observations, however, maintain differences exist among the alkaline resistant haemoglobin fractions. Thus S in

Journal

Acta Haematologica – Karger

Published: Jan 1, 2009

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