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- Publisher
- Karger
- Copyright
- © 2009 S. Karger AG, Basel
- ISSN
- 2296-5270
- eISSN
- 2296-5262
- DOI
- 10.1159/000209321
- Publisher site
- See Article on Publisher Site
Abstract
Background: To date, only a few cases have been reported that indicate that a delayed polyneuropathy may occur after chemotherapy with oxaliplatin. The clinical and electrophysiological manifestations of this delayed neurotoxicity have never been well documented. Case Reports: Nerve conduction studies were performed in 4 patients who developed acute peripheral neuropathy several months after completion of oxaliplatin-containing chemotherapy. Sensory nerve conduction was abnormal in all patients. In 2 patients, the electrodiagnostic studies showed a mixed axonal and demyelinating sensorimotor polyneuropathy. Conclusions: Delayed polyneuropathy occurring after oxaliplatin-based chemotherapy can be confirmed by electrophysiological studies.
Journal
Oncology Research and Treatment – Karger
Published: Jan 1, 2009
Keywords: Oxaliplatin; Polyneuropathy; Neurotoxicity