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Biochemical and Histochemical Changes in Energy Supply-Enzyme Pattern of Muscles of the Rat during Old Age

Biochemical and Histochemical Changes in Energy Supply-Enzyme Pattern of Muscles of the Rat... Senile muscles of the rat (28–36 months) show loss of overall activity of glycolytic and aerobic enzymes. However, there is a differential loss and shift of enzyme activity pattern in the three types of muscles. The extensor digitorum longus (EDL) and diaphragm show a decrease of ratios of glycolytic to aerobic-oxidative enzymes. This shift to a more oxidative type of metabolism is not observed in the soleus muscle. Decrease of enzyme activities is least marked in the diaphragm muscle. Biochemical analysis shows a trend to levelling out of metabolic differences between the different muscle types. This trend of ‘dedifferentiation’ is most marked when comparing EDL and soleus, least marked when comparing EDL and diaphragm muscle. The histochemical analysis shows a shift from the original mixed to a more uniform pattern of muscle fibres in the EDL and soleus muscle; this levelling-out of differences between enzymatic activities of different muscle fibres is not observed in the diaphragm muscle. Preferential atrophy and loss of ATPase activity in type II muscle fibres in the soleus muscle and the occurrence of ‘type grouping’ are further characteristic features of senile muscle change. The findings show general (i.e. loss of enzyme activities) and differential trends of biochemical and histochemical enzyme changes in different types of muscles. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Gerontology Karger

Biochemical and Histochemical Changes in Energy Supply-Enzyme Pattern of Muscles of the Rat during Old Age

Bass, A.; Gutmann, E.; Hanzlíková, V.
Gerontology , Volume 21 (1): 15 – Jan 1, 1975
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Publisher
Karger
Copyright
© 1975 S. Karger AG, Basel
ISSN
0304-324X
eISSN
1423-0003
DOI
10.1159/000212028
Publisher site
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Abstract

Senile muscles of the rat (28–36 months) show loss of overall activity of glycolytic and aerobic enzymes. However, there is a differential loss and shift of enzyme activity pattern in the three types of muscles. The extensor digitorum longus (EDL) and diaphragm show a decrease of ratios of glycolytic to aerobic-oxidative enzymes. This shift to a more oxidative type of metabolism is not observed in the soleus muscle. Decrease of enzyme activities is least marked in the diaphragm muscle. Biochemical analysis shows a trend to levelling out of metabolic differences between the different muscle types. This trend of ‘dedifferentiation’ is most marked when comparing EDL and soleus, least marked when comparing EDL and diaphragm muscle. The histochemical analysis shows a shift from the original mixed to a more uniform pattern of muscle fibres in the EDL and soleus muscle; this levelling-out of differences between enzymatic activities of different muscle fibres is not observed in the diaphragm muscle. Preferential atrophy and loss of ATPase activity in type II muscle fibres in the soleus muscle and the occurrence of ‘type grouping’ are further characteristic features of senile muscle change. The findings show general (i.e. loss of enzyme activities) and differential trends of biochemical and histochemical enzyme changes in different types of muscles.

Journal

Gerontology – Karger

Published: Jan 1, 1975

Keywords: Rat; Energy metabolism; Muscle; Enzyme pattern

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