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Assignment of the Major Histocompatibility Complex to Chromosome No. 6 in a Family with a Pericentric Inversion

Assignment of the Major Histocompatibility Complex to Chromosome No. 6 in a Family with a... In a family with a large pericentric inversion in one chromosome No. 6 (Inv(6)(p+q–)), HL-A was shown to have segregated with this chromosome in seven of seven cases. This raises the probability for the localization of HL-A to chromosome No. 6 from a prior 6 to 49 % and confirms the same assignment reported from cell hybridization work. The HL-A locus is most likely to be a little distal to the midpoint of either the short or the long arm of chromosome No. 6. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Human Heredity Karger

Assignment of the Major Histocompatibility Complex to Chromosome No. 6 in a Family with a Pericentric Inversion

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Publisher
Karger
Copyright
© 1974 S. Karger AG, Basel
ISSN
0001-5652
eISSN
1423-0062
DOI
10.1159/000152660
Publisher site
See Article on Publisher Site

Abstract

In a family with a large pericentric inversion in one chromosome No. 6 (Inv(6)(p+q–)), HL-A was shown to have segregated with this chromosome in seven of seven cases. This raises the probability for the localization of HL-A to chromosome No. 6 from a prior 6 to 49 % and confirms the same assignment reported from cell hybridization work. The HL-A locus is most likely to be a little distal to the midpoint of either the short or the long arm of chromosome No. 6.

Journal

Human Heredity – Karger

Published: Jan 1, 2008

Keywords: HL-A linkage group; Chromosome 6; Inversion chromosome No. 6; HL-A assignment to 6; Gene assignment

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