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Cytogenet Cell Genet 83:58–59 (1998) Assignment of STAT1 to human chromosome 2q32 by FISH and radiation hybrids a,b c b c,d B. Haddad, C.R. Pabo ´ n-Peña, H. Young and W.H. Sun Department of Obstetrics and Gynecology and Institute for Molecular and Human Genetics, Georgetown University Medical Center, Washington DC; Division of Dermatology, Department of Pediatrics, Children’s Memorial Hospital; Robert Lurie Comprehensive Cancer Center, Northwestern University Medical School, Chicago IL (USA) This is a confirmation and a more precise localization of the human STAT1 gene previously mapped to chromo- some 2q32 by Yamamoto et al. (1997). (Leica). Fluorescein and DAPI fluorescence were recorded separately as gray Rationale and significance scale images then merged using the software package NIH 1.57 (Ijdo et al., 1992) and band assignment of the fluorescein signals was done. The signal transducer and activator of transcription (STAT) molecules constitute a family of latent transcription factors. RH Mapping Activated STATs can form homo- or heterodimers which trans- The Genebridge 4 panel is composed of 93 independent somatic cell hybrids, each representing a fusion event between an X-irradiated donor locate into the nucleus where specific DNA binding and regula- human lymphoblastoid cell and a recipient Chinese hamster cell.
Cytogenetic and Genome Research – Karger
Published: Jan 1, 1998
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