Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/karger/alterations-in-gentamicin-pharmacokinetics-during-neonatal-exchange-S0fT8EoKwF
References
References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.
- Publisher
- Karger
- Copyright
- © 1982 S. Karger AG, Basel
- ISSN
- 0379-8305
- eISSN
- 2504-2505
- DOI
- 10.1159/000457409
- Publisher site
- See Article on Publisher Site
Abstract
The effect of double volume exchange transfusion on the pharmacokineticsof gentamicin was studied in 7 neonates undergoing eight transfusions. The procedureswere performed an average of 9.6 h following the previous dose of drug and required anaverage of 0.91 h to complete. Exchange transfusion decreased serum gentamicin concentrationsby 18.5 ± 4.2% and increased the elimination rate for gentamicin by 31.8%.Serum concentrations obtained an average of 3.3 h following the procedure showed arebound increase in concentration compared to that obtained just at the end of the transfusion(2 cases), no change (1 case) or a decrease compared with the immediate posttransfusionperiod (5 cases). The results observed in the late posttransfusion period were foundto be inversely related (r = -0.78) to the number of doses received by the patient prior tothe procedure. A one-compartment pharmacokinetic model was found to be adequate inpredicting the amount of drug removed by the procedure while a two-compartment modelbest described the posttransfusion alteration in elimination kinetics.
Journal
Developmental Pharmacology and Therapeutics – Karger
Published: Jan 1, 2017
Keywords: Premature infants; Exchange transfusion; Gentamicin; Pharmacokinetics