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Abrupt Coronary Occlusion and Left Ventricular Ejection during Coronary Angioplasty

Abrupt Coronary Occlusion and Left Ventricular Ejection during Coronary Angioplasty The effects of abrupt coronary occlusion on left ventricular ejection were studied during percutaneoustransluminal coronary angioplasty. Measurements of blood velocities in the ascending aorta were used to determinepeak acceleration, peak velocity, and stroke integral of left ventricular ejection during and immediately after balloonocclusion at 31 intracoronary sites in 25 patients. Compared to preinflation values, small but statistically significant(P < 0 .05) decreases occurred for peak acceleration (16.3 ± 1.3 to 15.0 ± 1.4 m/s/s), peak velocity (63 ± 4.7 to 58 ±4.3 cm/s), and stroke integral (10.0 ± 0.7 to 9.0 ± 0.7 cm; mean ± SE). All three ejection indices returned topreinflation values immediately after balloon deflation. When subgrouped according to proximal (n = 16 sites in 16patients) and nonproximal occlusion (n = 15 sites in 9 patients), significant (p < 0.01) decreases occurred for peakacceleration (18.2 ± 1.4 to 15.8 ± 1.5 m/s/s), peak velocity (69 ± 4.3 to 59 ± 4.0 cm/s), and stroke integral (10.2 ±0.7 to 8.8 ± 0.6 cm) only after proximal occlusion. Reperfusion after proximal occlusion resulted in a small butsignificant (p < 0.05) increase in peak acceleration (18.2 ± 1.4 to 19.6 ± 1.5 m/s/s) relative to preinflation values.This study demonstrates that ischemia resulting from abrupt coronary occlusion in humans can result in rapiddecreases in maximum acceleration and velocity of ascending aortic blood flow which are rapidly reversible withreperfusion. Accordingly, these indices may be useful for noninvasi ve assessments of the functional significance oftransient episodes of myocardial ischemia. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Noninvasive Cardiology Karger

Abrupt Coronary Occlusion and Left Ventricular Ejection during Coronary Angioplasty

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Publisher
Karger
Copyright
© 1989 S. Karger AG, Basel
ISSN
0258-4425
eISSN
2504-2378
DOI
10.1159/000470598
Publisher site
See Article on Publisher Site

Abstract

The effects of abrupt coronary occlusion on left ventricular ejection were studied during percutaneoustransluminal coronary angioplasty. Measurements of blood velocities in the ascending aorta were used to determinepeak acceleration, peak velocity, and stroke integral of left ventricular ejection during and immediately after balloonocclusion at 31 intracoronary sites in 25 patients. Compared to preinflation values, small but statistically significant(P < 0 .05) decreases occurred for peak acceleration (16.3 ± 1.3 to 15.0 ± 1.4 m/s/s), peak velocity (63 ± 4.7 to 58 ±4.3 cm/s), and stroke integral (10.0 ± 0.7 to 9.0 ± 0.7 cm; mean ± SE). All three ejection indices returned topreinflation values immediately after balloon deflation. When subgrouped according to proximal (n = 16 sites in 16patients) and nonproximal occlusion (n = 15 sites in 9 patients), significant (p < 0.01) decreases occurred for peakacceleration (18.2 ± 1.4 to 15.8 ± 1.5 m/s/s), peak velocity (69 ± 4.3 to 59 ± 4.0 cm/s), and stroke integral (10.2 ±0.7 to 8.8 ± 0.6 cm) only after proximal occlusion. Reperfusion after proximal occlusion resulted in a small butsignificant (p < 0.05) increase in peak acceleration (18.2 ± 1.4 to 19.6 ± 1.5 m/s/s) relative to preinflation values.This study demonstrates that ischemia resulting from abrupt coronary occlusion in humans can result in rapiddecreases in maximum acceleration and velocity of ascending aortic blood flow which are rapidly reversible withreperfusion. Accordingly, these indices may be useful for noninvasi ve assessments of the functional significance oftransient episodes of myocardial ischemia.

Journal

American Journal of Noninvasive Cardiology – Karger

Published: Jan 1, 2017

Keywords: Ventricular performance; Coronary artery disease; Doppler ultrasound; Percutaneous transluminal coronary angioplasty

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