Letters 1. Parasrampuria DA, Mendell J, Shi M, Matsushima N, Zahir H, Truitt K. frailty, may still exist. Some covariates (eg, categories of Edoxaban drug-drug interactions with ketoconazole, erythromycin, and liver diseases) can act as a proxy for laboratory tests. Frailty cyclosporine. Br J Clin Pharmacol. 2016;82(6):1591-1600. is difficult to measure and quantify clinically. Self-controlled 2. Heidbuchel H, Verhamme P, Alings M, et al. Updated European Heart design, as advised by Li and colleagues, may be needed to Rhythm Association practical guide on the use of non–vitamin-K antagonist ascertain its influence. Specific drug characteristics, for anticoagulants in patients with non-valvular atrial fibrillation. Eur Heart J.2017; 38(27):2137-2149. example thrombocytopenia associated with rifampin, may 3. Romley JA, Gong C, Jena AB, Goldman DP, Williams B, Peters A. Association change bleeding risk beyond the influence of altered NOAC between use of warfarin with common sulfonylureas and serious hypoglycemic levels. Drug-disease interactions also make the risk estima- events. BMJ. 2015;351:h6223. tion of adverse drug reactions more difficult. Wang and col- 4. Grosset J, Leventis S. Adverse effects of rifampin. Rev Infect Dis. 1983; leagues comment that the increased risk associated with 5(suppl 3):S440-S450. phenytoin may be a bystander of intracranial hemorrhage 5. Dumbreck
JAMA – American Medical Association
Published: Feb 27, 2018
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