Letters COMMENT & RESPONSE of this tool has even been demonstrated in regional Australia, with a group reporting that PSMA PET/CT changed manage- Prostate-Specific Membrane Antigen Positron ment in 53.7% of patients receiving radiotherapy. Emission Tomography/Computed Tomography Undoubtedly, Ga PSMA PET/CT represents a promising in Locally Advanced, Recurrent, and Metastatic diagnostic tool in the armamentarium of clinicians in the set- Prostate Cancer ting of primary and recurrent prostate cancer, and it is clear that To the Editor We read with great interest the recent article by this is in widespread clinical use outside of research protocols. Lindenberg et al. We commend the authors on a timely and While uptake and availability of Ga PSMA PET/CT in the comprehensive review in this important topic. However, there Americas is limited, the global experience is considerable and are several inconsistencies and inaccuracies that we believe should be acknowledged. necessitate clarification. First, the authors highlight the naive nature of gallium ci- Marlon Perera, MBBS, BMedSci trate ( Ga) prostate-specific membrane antigen (PSMA) posi- Declan Murphy, MBBCh, FRACS, FRCS tron emission tomography/computed tomography (PET/CT) in Nathan Lawrentschuk, MBBS, PhD, FRACS current practice and discuss that histological validation is in- complete. However, in a recent
JAMA Oncology – American Medical Association
Published: Jun 22, 2018
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