News & Analysis Health Agencies Update Plant-Chemical Shows Promise mal iodine levels or mild iodine deficiency, for Pain Relief women with iodine-creatine ratios lower A chemical from the cactuslike plant than 50 μg/g had a 46% lower chance of be- Euphorbia resinifera found in Morocco coming pregnant in any menstrual cycle. reduces postsurgical pain in rats, according Women with milder iodine deficiencies of to a study by researchers from the National between 50 and 99 μg/g also took longer to Institutes of Health’s (NIH’s) Clinical Center. conceive than women with sufficient io- These findings are the latest in a string dine levels, but the difference wasn’t statis- of studies that suggest resiniferatoxin tically significant. may offer an alternative to opioid pain “Our findings suggest that women who relievers. In fact, the NIH’s Clinical Center arethinkingofbecomingpregnantmayneed already has a phase 1 clinical trial under more iodine,” said lead author James L. Mills, way to test whether an injection of the MD, a senior investigator at NICHD in a state- chemical into the central nervous system ment. “Iodine requirements increase dur- eases pain associated with advanced can- ingpregnancy,andthefetusdependsonthis cer. Resiniferatoxin is chemically similar to mineral to make thyroid hormone and to
JAMA – American Medical Association
Published: Feb 27, 2018
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