Opinion EDITORIAL Menopausal Hormone Therapy for the Primary Prevention of Chronic Conditions Unfulfilled Expectations Nanette K. Wenger, MD In 1968, Robert A. Wilson, MD, a New York gynecologist, pub- up, although almost half of the women originally assigned to lished Feminine Forever. In that book, he advocated that meno- hormone therapy continued to take it. The authors con- pause was preventable and that hormone replacement therapy, cluded that this hormone regimen did not reduce risk of car- as it was called at that time, would preserve the woman’s youth- diovascular events (eg, revascularization, unstable angina, ful appearance, keep her heart failure, or stroke). Regarding noncoronary outcomes in sexually attractive and po- HERS II, increased risks of venous thromboembolism and bili- Related article at jama.com tent, and preserve the ary tract surgery were noted, but there was no significant ef- strength of her bones. He fur- fect on breast cancer, any cancer, hip fracture, or any frac- ther proposed that it could prevent breast and genital cancers ture. as well as tension, irritability, headache, fatigue, depression, Pivotal data derive from the randomized clinical trials of and insomnia. By the mid-1970s, about 30 million prescrip- hormones in the Women’s Health Initiative
JAMA Cardiology – American Medical Association
Published: Feb 12, 2018
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