JAMA Cardiology

JAMA Cardiology Editor Editor in Chief, The JAMA Network Robert O. Bonow, MD, MS Howard Bauchner, MD Mission Statement JAMA Cardiology publishes exceptional original research, state-of-the-art focuses on all aspects of cardiovascular medicine, including epidemiology and prevention, reviews, and informative opinions that advance the science and practice of cardiology, enhance diagnostic testing, interventional and pharmacologic therapeutics, translational research, health cardiovascular health, and inform health care policy. JAMA Cardiology is the defi nitive journal for care policy and outcomes, and global health. clinical investigators, clinicians, and trainees in cardiovascular medicine worldwide. JAMA Cardiology DEPUTY EDITORS SECTION EDITORS EDITORIAL BOARD INTERNATIONAL ADVISORY BOARD Robert A. Harrington, MD Associate Editor for Health Care Quality Eugene Braunwald, MD Paul W. Armstrong, MD Stanford, California and Guidelines Boston, Massachusetts Edmonton, Alberta, Canada Gregg C. Fonarow, MD Marc S. Sabatine, MD, MPH Robert Califf , MD Shinya Goto, MD, PhD Los Angeles, California Boston, Massachusetts Durham, North Carolina Isehara, Japan Associate Editor for Clyde W. Yancy, MD, MSc Judith S. Hochman, MD Peter Liu, MD Translational Science Chicago, Illinois New York, New York Ottawa, Ontario, Canada Elizabeth M. McNally, MD, PhD Donald M. Lloyd-Jones, MD, ScM Renato D. Lopes, MD, MHS, PhD Chicago, Illinois DEPUTY EDITOR FOR STATISTICS Chicago, Illinois Durham, North Carolina Mintu Turakhia, MD, MAS Michael J. Pencina, PhD Michael S. Parmacek, MD Attilio Maseri, MD Palo Alto, California Durham, North Carolina Philadelphia, Pennsylvania Firenze, Italy Assistant Editor for Statistics Daniel I. Simon, MD Dorairaj Prabhakaran, MD, DM, MSc Laine Elliott Thomas, PhD ASSOCIATE EDITORS Cleveland, Ohio Haryana, India Durham, North Carolina Adrian F. Hernandez, MD, MHS Sidney C. Smith Jr, MD Hugh C. Watkins, MD, PhD Editorial Offi ce Manager Durham, North Carolina Chapel Hill, North Carolina Oxford, England Julia Getts, Chicago, Illinois Mark D. Huff man, MD, MPH Douglas E. Vaughan, MD Harvey D. White, MB, ChB, DSc Editorial Offi ce Chicago, Illinois Chicago, Illinois Auckland, New Zealand Ajay J. Kirtane, MD, SM Myron L. Weisfeldt, MD Sir Magdi Habib Yacoub, OM, FRS c/o Department of Medicine New York, New York Baltimore, Maryland London, England 251 E Huron St Christopher J. O’Donnell, MD, MPH Galter 3-150 Douglas P. Zipes, MD Boston, Massachusetts Chicago, IL 60611 Indianapolis, Indiana Patrick T. O’Gara, MD Telephone: 312-926-7252 Boston, Massachusetts jamacardio@jamanetwork.org Sanjiv J. Shah, MD Chicago, Illinois Mintu Turakhia, MD, MAS Palo Alto, California PUBLICATION STAFF Scientifi c Online Resources PERIODICAL PUBLISHING STAFF Associate Publisher/Senior Product Deputy Editor and Director Development Geoff rey Flick Executive Editor Senior Vice President and Publisher, Michael Berkwits, MD Managers Rick Bell, Fergus Clare, Phil B. Fontanarosa, MD, MBA Periodical Publications Lindsay Dawson, Will English IV, Ellen Gibson, Digital Media Production Thomas J. Easley Executive Managing Editor Mustafa Ishaq, Craig McCaff rey, Eric Butkus, Michelle Kurzynski (managers); Annette Flanagin Vice President, Michael McGraw, Daniel Pickhardt, Emily Ling, Jesse McQuarters, Daniel Morrow Publishing Business Operations Managing Editor Romando Rossini, Stacy Tucker (producers) Brian Shields Brenda Gregoline Business Analyst Sirisha Alluri Social Media Daniella Peting (manager); Vice President, Staff Millette Jackson-Bates Deputy Managing Editor Reuben Rios (coordinator) Publishing Production Operations Tracy Frey Business Operations Electronic Media Systems and Services Karen Adams-Taylor Directors Karl Elvin, Nancy Essex, Jaye Mize, Manuscript Editors Carrie Butt (supervisor); Mary Lynn Ferkaluk Vice President, Sean O’Donnell, Sue Sherrill Kevin Brown, Amanda Ehrhardt, Iris Y. Lo, (assistant) Digital Product Management Michaela Mark, M. Sophia Newman, Managers David Antos, Chris Borden, Editorial Graphics and Development Suzanne Walker Debbie Camp, Lydia Cruz, Scott Curl, Deputy Editor and Director Paul Gee Freelance Manuscript Editing Manager Diane Darnell, Jordynn Farrar, Tiff any Jones, Ronna Henry, MD Staff Monica Smith Colleen Kelly, Chris Meyer, Annemarie Neff , Connie L. Manno Staff Karen Bucher, Andy Rekito, Nick Reback, J.D. Neff , Sean Ohlson, Phil O’Leary, Bill Pedone, Advertising Print & Online Sales Freelance Manuscript Editing Coordinators David Song Susan Price, Binita Shah, Denise Steinhauser, & Marketing Sara M. Billings, Timothy Gray, Paul Ruich Clinical Review & Education Erin Van Dusen, Joe Wixted Director Jeff ery J. Bonistalli Freelance Copy Editors and Copyreaders Deputy Editor Edward H. Livingston, MD Manager Kathy Russell Advertising and Production Services Catherine A. Alden, Stephanie Lang Beckmeyer, Staff Mirna Monal CME Editor Thomas B. Cole, MD, MPH Ahmed Avendano, Kim Boler, Jan Clavey, Mary Coerver-Connolly, Sales Representatives Stacey McHugh, Rhonda Bailey Brown, Fin Carter, Paula Glitman, Laura King, Joseph Clayton Mills, Budgets and Administration Tim Melroy Michael Deegan, Daniel DeGroot, Director Marla A. Hall Brandy Y. Patton, Donna J. Thordsen Director, Marketing Mark Thornbury Euwanaha Joiner-Smith, Joshua Lane, Editorial Assistant Wanda Hill Staff Deanna Willis, Yolanda Davis Staff Tricia Castellano Cindy Rendlen, Ellen Yoshihara Editorial Operations & Systems Editorial Counsel Classifi ed Advertising Circulation Services Julie Burton, Mary Sieck, Directors Larry Bryant, Joseph P. Thornton, JD Manager Thalia Moss Sarah Subramanian, Geneine Van Someren Monica Mungle, Elaine Williams Media Relations Staff Tiff ani Stevenson Composition and New Media Gail Barrett, Managers and Staff Fanny L. Brown, Manager Deanna Bellandi Reprint Communications Regina Brownlee, Amanda Camino, Lenette Gardner-Gullens, Erin Kato, Staff Jim Michalski Manager Susan Lovenberg Brenda Chandler-Grayer, Emily Dunn, Peter K. Kim, Rachell Lozano, Amy Evers, Maleeka Holden, Teri Hutchison, Circulation Print & Online Sales Caroline Sietmann, Angelia Waltower, Mary Ann Kuranda, Joshua Lampinen, & Marketing Elizabeth Zak Nathan Mitre, Patricia E. Panek, Director, Worldwide Sales Vida Damijonaitis La’son Diggs Sledge Managers Saskia Bolore, Gretchen Linder, Brian McCartney Graphics Joe Amft, Maria Duda, Fred Furtner, Carolyn Hall, Maria Kowalkowski Sales Representatives Christine Hearne, Natasha Nekola Proofreading Carol Joy Farrell, Daniel James, Judith A. Literskis, Teresa H. Omiotek, Staff David Baum, Ron Thomas Michael Ryder Marketing and Product Development Director Elizabeth Solaro AMA EXECUTIVES The JAMA Network is a consortium of peer-reviewed print and online medical publications that includes JAMA®, JAMA Cardiology, and other specialty journals. JAMA Cardiology does not hold itself Executive Vice President, responsible for statements made by any contributor. All articles published, including opinion articles, Chief Executive Offi cer represent the views of the authors and do not refl ect the policy of the Journal, the American Medical James L. Madara, MD Association, or the institution with which the author is affi liated, unless otherwise indicated. Chief Operating Offi cer © 2018 American Medical Association. All rights reserved. Reproduction without permission is prohibited. Bernard L. Hengesbaugh 96 JAMA Cardiology February 2018 Volume 3, Number 2 jamacardiology.com Copyright 2018 American Medical Association. All rights reserved. Copyright 2018 American Medical Association. All rights reserved. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Cardiology American Medical Association

JAMA Cardiology

JAMA Cardiology , Volume 3 (2) – Feb 1, 2018
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Publisher
American Medical Association
Copyright
Copyright 2018 American Medical Association. All Rights Reserved.
ISSN
2380-6583
eISSN
2380-6591
D.O.I.
10.1001/jamacardio.2017.3347
Publisher site
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Abstract

Editor Editor in Chief, The JAMA Network Robert O. Bonow, MD, MS Howard Bauchner, MD Mission Statement JAMA Cardiology publishes exceptional original research, state-of-the-art focuses on all aspects of cardiovascular medicine, including epidemiology and prevention, reviews, and informative opinions that advance the science and practice of cardiology, enhance diagnostic testing, interventional and pharmacologic therapeutics, translational research, health cardiovascular health, and inform health care policy. JAMA Cardiology is the defi nitive journal for care policy and outcomes, and global health. clinical investigators, clinicians, and trainees in cardiovascular medicine worldwide. JAMA Cardiology DEPUTY EDITORS SECTION EDITORS EDITORIAL BOARD INTERNATIONAL ADVISORY BOARD Robert A. Harrington, MD Associate Editor for Health Care Quality Eugene Braunwald, MD Paul W. Armstrong, MD Stanford, California and Guidelines Boston, Massachusetts Edmonton, Alberta, Canada Gregg C. Fonarow, MD Marc S. Sabatine, MD, MPH Robert Califf , MD Shinya Goto, MD, PhD Los Angeles, California Boston, Massachusetts Durham, North Carolina Isehara, Japan Associate Editor for Clyde W. Yancy, MD, MSc Judith S. Hochman, MD Peter Liu, MD Translational Science Chicago, Illinois New York, New York Ottawa, Ontario, Canada Elizabeth M. McNally, MD, PhD Donald M. Lloyd-Jones, MD, ScM Renato D. Lopes, MD, MHS, PhD Chicago, Illinois DEPUTY EDITOR FOR STATISTICS Chicago, Illinois Durham, North Carolina Mintu Turakhia, MD, MAS Michael J. Pencina, PhD Michael S. Parmacek, MD Attilio Maseri, MD Palo Alto, California Durham, North Carolina Philadelphia, Pennsylvania Firenze, Italy Assistant Editor for Statistics Daniel I. Simon, MD Dorairaj Prabhakaran, MD, DM, MSc Laine Elliott Thomas, PhD ASSOCIATE EDITORS Cleveland, Ohio Haryana, India Durham, North Carolina Adrian F. Hernandez, MD, MHS Sidney C. Smith Jr, MD Hugh C. Watkins, MD, PhD Editorial Offi ce Manager Durham, North Carolina Chapel Hill, North Carolina Oxford, England Julia Getts, Chicago, Illinois Mark D. Huff man, MD, MPH Douglas E. Vaughan, MD Harvey D. White, MB, ChB, DSc Editorial Offi ce Chicago, Illinois Chicago, Illinois Auckland, New Zealand Ajay J. Kirtane, MD, SM Myron L. Weisfeldt, MD Sir Magdi Habib Yacoub, OM, FRS c/o Department of Medicine New York, New York Baltimore, Maryland London, England 251 E Huron St Christopher J. O’Donnell, MD, MPH Galter 3-150 Douglas P. Zipes, MD Boston, Massachusetts Chicago, IL 60611 Indianapolis, Indiana Patrick T. O’Gara, MD Telephone: 312-926-7252 Boston, Massachusetts jamacardio@jamanetwork.org Sanjiv J. Shah, MD Chicago, Illinois Mintu Turakhia, MD, MAS Palo Alto, California PUBLICATION STAFF Scientifi c Online Resources PERIODICAL PUBLISHING STAFF Associate Publisher/Senior Product Deputy Editor and Director Development Geoff rey Flick Executive Editor Senior Vice President and Publisher, Michael Berkwits, MD Managers Rick Bell, Fergus Clare, Phil B. Fontanarosa, MD, MBA Periodical Publications Lindsay Dawson, Will English IV, Ellen Gibson, Digital Media Production Thomas J. Easley Executive Managing Editor Mustafa Ishaq, Craig McCaff rey, Eric Butkus, Michelle Kurzynski (managers); Annette Flanagin Vice President, Michael McGraw, Daniel Pickhardt, Emily Ling, Jesse McQuarters, Daniel Morrow Publishing Business Operations Managing Editor Romando Rossini, Stacy Tucker (producers) Brian Shields Brenda Gregoline Business Analyst Sirisha Alluri Social Media Daniella Peting (manager); Vice President, Staff Millette Jackson-Bates Deputy Managing Editor Reuben Rios (coordinator) Publishing Production Operations Tracy Frey Business Operations Electronic Media Systems and Services Karen Adams-Taylor Directors Karl Elvin, Nancy Essex, Jaye Mize, Manuscript Editors Carrie Butt (supervisor); Mary Lynn Ferkaluk Vice President, Sean O’Donnell, Sue Sherrill Kevin Brown, Amanda Ehrhardt, Iris Y. Lo, (assistant) Digital Product Management Michaela Mark, M. Sophia Newman, Managers David Antos, Chris Borden, Editorial Graphics and Development Suzanne Walker Debbie Camp, Lydia Cruz, Scott Curl, Deputy Editor and Director Paul Gee Freelance Manuscript Editing Manager Diane Darnell, Jordynn Farrar, Tiff any Jones, Ronna Henry, MD Staff Monica Smith Colleen Kelly, Chris Meyer, Annemarie Neff , Connie L. Manno Staff Karen Bucher, Andy Rekito, Nick Reback, J.D. Neff , Sean Ohlson, Phil O’Leary, Bill Pedone, Advertising Print & Online Sales Freelance Manuscript Editing Coordinators David Song Susan Price, Binita Shah, Denise Steinhauser, & Marketing Sara M. Billings, Timothy Gray, Paul Ruich Clinical Review & Education Erin Van Dusen, Joe Wixted Director Jeff ery J. Bonistalli Freelance Copy Editors and Copyreaders Deputy Editor Edward H. Livingston, MD Manager Kathy Russell Advertising and Production Services Catherine A. Alden, Stephanie Lang Beckmeyer, Staff Mirna Monal CME Editor Thomas B. Cole, MD, MPH Ahmed Avendano, Kim Boler, Jan Clavey, Mary Coerver-Connolly, Sales Representatives Stacey McHugh, Rhonda Bailey Brown, Fin Carter, Paula Glitman, Laura King, Joseph Clayton Mills, Budgets and Administration Tim Melroy Michael Deegan, Daniel DeGroot, Director Marla A. Hall Brandy Y. Patton, Donna J. Thordsen Director, Marketing Mark Thornbury Euwanaha Joiner-Smith, Joshua Lane, Editorial Assistant Wanda Hill Staff Deanna Willis, Yolanda Davis Staff Tricia Castellano Cindy Rendlen, Ellen Yoshihara Editorial Operations & Systems Editorial Counsel Classifi ed Advertising Circulation Services Julie Burton, Mary Sieck, Directors Larry Bryant, Joseph P. Thornton, JD Manager Thalia Moss Sarah Subramanian, Geneine Van Someren Monica Mungle, Elaine Williams Media Relations Staff Tiff ani Stevenson Composition and New Media Gail Barrett, Managers and Staff Fanny L. Brown, Manager Deanna Bellandi Reprint Communications Regina Brownlee, Amanda Camino, Lenette Gardner-Gullens, Erin Kato, Staff Jim Michalski Manager Susan Lovenberg Brenda Chandler-Grayer, Emily Dunn, Peter K. Kim, Rachell Lozano, Amy Evers, Maleeka Holden, Teri Hutchison, Circulation Print & Online Sales Caroline Sietmann, Angelia Waltower, Mary Ann Kuranda, Joshua Lampinen, & Marketing Elizabeth Zak Nathan Mitre, Patricia E. Panek, Director, Worldwide Sales Vida Damijonaitis La’son Diggs Sledge Managers Saskia Bolore, Gretchen Linder, Brian McCartney Graphics Joe Amft, Maria Duda, Fred Furtner, Carolyn Hall, Maria Kowalkowski Sales Representatives Christine Hearne, Natasha Nekola Proofreading Carol Joy Farrell, Daniel James, Judith A. Literskis, Teresa H. Omiotek, Staff David Baum, Ron Thomas Michael Ryder Marketing and Product Development Director Elizabeth Solaro AMA EXECUTIVES The JAMA Network is a consortium of peer-reviewed print and online medical publications that includes JAMA®, JAMA Cardiology, and other specialty journals. JAMA Cardiology does not hold itself Executive Vice President, responsible for statements made by any contributor. All articles published, including opinion articles, Chief Executive Offi cer represent the views of the authors and do not refl ect the policy of the Journal, the American Medical James L. Madara, MD Association, or the institution with which the author is affi liated, unless otherwise indicated. Chief Operating Offi cer © 2018 American Medical Association. All rights reserved. Reproduction without permission is prohibited. Bernard L. Hengesbaugh 96 JAMA Cardiology February 2018 Volume 3, Number 2 jamacardiology.com Copyright 2018 American Medical Association. All rights reserved. Copyright 2018 American Medical Association. All rights reserved.

Journal

JAMA CardiologyAmerican Medical Association

Published: Feb 1, 2018

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