Opinion Editorial The well-designed study by Tun et al therefore has merits different factors affecting infant IM (eg, breastfeeding and early because of the addition of important information that sup- exposure to antibiotics) appear pivotal. Limited generalizabil- ports the view that maternal BMI and cesarean delivery coop- ity of the results (exclusive Canadian ethnicity) was also a limi- erate in shaping the microbial communities of early life, which tation. are associated with the development of OWOB in their off- Despite the limitations of the study by Tun et al, its spring. Nonetheless, their study has a number of limitations strengths include the large study population. They found that that should be taken into consideration by future confirma- richness in Firmicutes species and increased abundance of tory studies. In particular, a major limitation was the lack of Lachnospiraceae were important for the intergenerational maternal samples for IM analysis. Maternal vaginal and skin transmission of OWOB. Future studies are needed to confirm microbiota are also involved in the development of infant IM these results and to understand more deeply the multiple fac- but were not studied. Infant stool samples were collected only tors implicated in a hitherto still complex interplay. Further
JAMA Pediatrics – American Medical Association
Published: Apr 26, 2018
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