Key PointsQuestionIn ICU patients receiving invasive ventilation, is a strategy using on-demand nebulization of acetylcysteine or salbutamol inferior to using routine nebulization of acetylcysteine with salbutamol with respect to days ventilator-free and alive at day 28? FindingsIn this randomized clinical trial that included 922 ICU patients receiving invasive ventilation who were expected to not be extubated within 24 hours, on-demand compared with routine nebulization of acetylcysteine with salbutamol resulted in 20 vs 21 days ventilator-free and alive at day 28, a difference that met the noninferiority margin of −0.5 days. MeaningAmong ICU patients receiving invasive ventilation, on-demand nebulization was not inferior to routine nebulization of acetylcysteine with salbutamol.
JAMA – American Medical Association
Published: Mar 13, 2018
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