Effect of Meropenem-Vaborbactam vs Piperacillin-Tazobactam on Clinical Cure or Improvement and Microbial Eradication in Complicated Urinary Tract Infection

Effect of Meropenem-Vaborbactam vs Piperacillin-Tazobactam on Clinical Cure or Improvement and... Key PointsQuestionWhat are the comparative effects of meropenem-vaborbactam vs piperacillin-tazobactam for treatment of complicated urinary tract infection, including acute pyelonephritis? FindingsIn this noninferiority randomized trial that included 550 patients, the difference in the composite outcome of complete resolution or improvement of symptoms along with microbial eradication met the noninferiority margin of 15% when comparing meropenem-vaborbactam vs piperacillin-tazobactam (98.4% vs 94.0%). MeaningThis study demonstrated noninferiority of meropenem-vaborbactam for the treatment of complicated urinary tract infection. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

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Publisher
American Medical Association
Copyright
Copyright 2018 American Medical Association. All Rights Reserved.
ISSN
0098-7484
eISSN
1538-3598
D.O.I.
10.1001/jama.2018.0438
Publisher site
See Article on Publisher Site

Abstract

Key PointsQuestionWhat are the comparative effects of meropenem-vaborbactam vs piperacillin-tazobactam for treatment of complicated urinary tract infection, including acute pyelonephritis? FindingsIn this noninferiority randomized trial that included 550 patients, the difference in the composite outcome of complete resolution or improvement of symptoms along with microbial eradication met the noninferiority margin of 15% when comparing meropenem-vaborbactam vs piperacillin-tazobactam (98.4% vs 94.0%). MeaningThis study demonstrated noninferiority of meropenem-vaborbactam for the treatment of complicated urinary tract infection.

Journal

JAMAAmerican Medical Association

Published: Feb 27, 2018

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