Defining the Most Appropriate Primary End Point in Phase 2 Trials of Immune Checkpoint Inhibitors for Advanced Solid Cancers

Defining the Most Appropriate Primary End Point in Phase 2 Trials of Immune Checkpoint Inhibitors... Key PointsQuestionWhat is the most appropriate primary end point in phase 2 trials of checkpoint inhibitors? FindingsIn this systematic review and meta-analysis of phase 2 and phase 3 trials of checkpoint inhibitors in advanced solid cancers, response rate correlated poorly with overall survival, but 6-month progression-free survival was a better predictor of 12-month overall survival. MeaningSix-month progression-free survival is recommended in place of response rate as an end point in future phase 2 checkpoint-inhibitor trials. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Oncology American Medical Association

Defining the Most Appropriate Primary End Point in Phase 2 Trials of Immune Checkpoint Inhibitors for Advanced Solid Cancers

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Publisher
American Medical Association
Copyright
Copyright 2018 American Medical Association. All Rights Reserved.
ISSN
2374-2437
eISSN
2374-2445
D.O.I.
10.1001/jamaoncol.2017.5236
Publisher site
See Article on Publisher Site

Abstract

Key PointsQuestionWhat is the most appropriate primary end point in phase 2 trials of checkpoint inhibitors? FindingsIn this systematic review and meta-analysis of phase 2 and phase 3 trials of checkpoint inhibitors in advanced solid cancers, response rate correlated poorly with overall survival, but 6-month progression-free survival was a better predictor of 12-month overall survival. MeaningSix-month progression-free survival is recommended in place of response rate as an end point in future phase 2 checkpoint-inhibitor trials.

Journal

JAMA OncologyAmerican Medical Association

Published: Apr 22, 2018

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