Comparison of Monthly vs Treat-and-Extend Regimens for Individuals With Macular Edema Who Respond Well to Anti–Vascular Endothelial Growth Factor Medications

Comparison of Monthly vs Treat-and-Extend Regimens for Individuals With Macular Edema Who Respond... Key PointsQuestionDoes a treat-and-extend regimen of aflibercept or bevacizumab injections have outcomes similar to monthly injections in participants with macular edema associated with central retinal vein occlusion or hemiretinal vein occlusion who have exhibited a good response to 6 months of monthly injections? FindingsIn this secondary analysis of a randomized clinical trial, meaningful visual acuity differences at 12 months were not present in comparisons of participants who had received a treat-and-extend regimen vs patients who received monthly injections between months 6 and 12. MeaningBecause of the wide confidence intervals on visual acuity differences between the monthly and the treat-and-extend groups, caution is warranted before concluding that the 2 regimens are associated with similar vision outcomes. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Ophthalmology American Medical Association

Comparison of Monthly vs Treat-and-Extend Regimens for Individuals With Macular Edema Who Respond Well to Anti–Vascular Endothelial Growth Factor Medications

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Publisher
American Medical Association
Copyright
Copyright 2018 American Medical Association. All Rights Reserved.
ISSN
2168-6165
eISSN
2168-6173
D.O.I.
10.1001/jamaophthalmol.2017.6843
Publisher site
See Article on Publisher Site

Abstract

Key PointsQuestionDoes a treat-and-extend regimen of aflibercept or bevacizumab injections have outcomes similar to monthly injections in participants with macular edema associated with central retinal vein occlusion or hemiretinal vein occlusion who have exhibited a good response to 6 months of monthly injections? FindingsIn this secondary analysis of a randomized clinical trial, meaningful visual acuity differences at 12 months were not present in comparisons of participants who had received a treat-and-extend regimen vs patients who received monthly injections between months 6 and 12. MeaningBecause of the wide confidence intervals on visual acuity differences between the monthly and the treat-and-extend groups, caution is warranted before concluding that the 2 regimens are associated with similar vision outcomes.

Journal

JAMA OphthalmologyAmerican Medical Association

Published: Apr 24, 2018

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