Biased Estimates in Mendelian Randomization Studies Conducted in Unrepresentative Samples

Biased Estimates in Mendelian Randomization Studies Conducted in Unrepresentative Samples Letters 3 4 We agree that a CAC score of 0 in symptomatic patients may Lyall et al use mendelian randomization, an increasingly not represent low risk. On the other hand, as we showed in popular method to support stronger causal inferences in obser- healthy asymptomatic older people where risk assessment and vational data, but this does not protect against the potential bias drugprescriptionisthemainconsideration,aCACscoreof0most we describe. In the Avon Longitudinal Study of Parents and Chil- likely represents a much lower-risk individual. dren (ALSPAC), a large prospective cohort study in the United Kingdom, both body mass index and smoking predict atten- Philip Greenland, MD dance at subsequent assessment clinics. Genetic antecedents Yuichiro Yano, MD, PhD of factors, such as body mass index and smoking that influence Donald M. Lloyd-Jones, MD, ScM participation, will be subject to a similar bias, which we see in the ALSPAC. Author Affiliations: Department of Preventive Medicine, Northwestern The extent to which bias owing to selection will occur will University Feinberg School of Medicine, Chicago, Illinois (Greenland, Lloyd- depend on the particular association being explored and the op- Jones); Department of Preventive Medicine, University of Mississippi Medical erating selection mechanisms. We suggest that researchers con- Center, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Cardiology American Medical Association

Biased Estimates in Mendelian Randomization Studies Conducted in Unrepresentative Samples

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Publisher
American Medical Association
Copyright
Copyright 2017 American Medical Association. All Rights Reserved.
ISSN
2380-6583
eISSN
2380-6591
D.O.I.
10.1001/jamacardio.2017.4279
Publisher site
See Article on Publisher Site

Abstract

Letters 3 4 We agree that a CAC score of 0 in symptomatic patients may Lyall et al use mendelian randomization, an increasingly not represent low risk. On the other hand, as we showed in popular method to support stronger causal inferences in obser- healthy asymptomatic older people where risk assessment and vational data, but this does not protect against the potential bias drugprescriptionisthemainconsideration,aCACscoreof0most we describe. In the Avon Longitudinal Study of Parents and Chil- likely represents a much lower-risk individual. dren (ALSPAC), a large prospective cohort study in the United Kingdom, both body mass index and smoking predict atten- Philip Greenland, MD dance at subsequent assessment clinics. Genetic antecedents Yuichiro Yano, MD, PhD of factors, such as body mass index and smoking that influence Donald M. Lloyd-Jones, MD, ScM participation, will be subject to a similar bias, which we see in the ALSPAC. Author Affiliations: Department of Preventive Medicine, Northwestern The extent to which bias owing to selection will occur will University Feinberg School of Medicine, Chicago, Illinois (Greenland, Lloyd- depend on the particular association being explored and the op- Jones); Department of Preventive Medicine, University of Mississippi Medical erating selection mechanisms. We suggest that researchers con- Center,

Journal

JAMA CardiologyAmerican Medical Association

Published: Feb 13, 2018

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