Association of Serum Retinol-Binding Protein 4 Concentration With Risk for and Prognosis of Amyotrophic Lateral Sclerosis

Association of Serum Retinol-Binding Protein 4 Concentration With Risk for and Prognosis of... Key PointsQuestionIs retinol-binding protein 4 (a specific carrier for retinol but also expressed in adipose tissue and found to be causally associated with insulin resistance) associated with risk for and prognosis of amyotrophic lateral sclerosis? FindingAmong 289 cases and 504 controls in this case-control cohort study, serum retinol-binding protein 4 concentration was inversely associated with risk for and prognosis of amyotrophic lateral sclerosis. Age, sex, and biomarkers for renal damage and fat mass (ie, leptin and adiponectin) did not substantially alter the association. MeaningIf corroborated in prospective studies, interventions resulting in high retinol-binding protein 4 concentration may point to a relevant pathogenetic pathway and indicate a potential target for therapeutic intervention. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Neurology American Medical Association

Association of Serum Retinol-Binding Protein 4 Concentration With Risk for and Prognosis of Amyotrophic Lateral Sclerosis

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Publisher
American Medical Association
Copyright
Copyright 2018 American Medical Association. All Rights Reserved.
ISSN
2168-6149
eISSN
2168-6157
D.O.I.
10.1001/jamaneurol.2017.5129
Publisher site
See Article on Publisher Site

Abstract

Key PointsQuestionIs retinol-binding protein 4 (a specific carrier for retinol but also expressed in adipose tissue and found to be causally associated with insulin resistance) associated with risk for and prognosis of amyotrophic lateral sclerosis? FindingAmong 289 cases and 504 controls in this case-control cohort study, serum retinol-binding protein 4 concentration was inversely associated with risk for and prognosis of amyotrophic lateral sclerosis. Age, sex, and biomarkers for renal damage and fat mass (ie, leptin and adiponectin) did not substantially alter the association. MeaningIf corroborated in prospective studies, interventions resulting in high retinol-binding protein 4 concentration may point to a relevant pathogenetic pathway and indicate a potential target for therapeutic intervention.

Journal

JAMA NeurologyAmerican Medical Association

Published: May 26, 2018

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