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Viral etiology in hospitalized children with acute respiratory tract infection in the Kegalle area of Sri Lanka

Viral etiology in hospitalized children with acute respiratory tract infection in the Kegalle... Acute respiratory tract infection (ARTI) is a leading cause of morbidity and mortality in children worldwide including Sri Lanka. This study was undertaken to determine the viral causes and clinical manifestations of ARTI in pre-school children (Age ⩽ 3 years) from the Kegalle area of the Sabaragamuwa Province of Sri Lanka. Nasopharyngeal aspirates (NPAs) from 98 children ⩽ 3 years presenting with ARTI were tested by indirect (screening) and direct (typing) immunofluorescence assay for the presence of respiratory syncytial virus (RSV), influenza A and B, parainfluenza viruses 1, 2 and 3 and adenoviruses. A respiratory virus was detected in 32.3% of cases: RSV 90%, parainfluenza type 2 virus 6% and influenza virus 4%. Detection of RSV was associated with severe cases of bronchiolitis requiring hospitalization. These findings show the importance of viral pathogens in ARTI in pre-school children in Sri Lanka and highlight the diversity of viral pathogens detected in this age group. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Pediatric Infectious Diseases IOS Press

Viral etiology in hospitalized children with acute respiratory tract infection in the Kegalle area of Sri Lanka

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Publisher
IOS Press
Copyright
Copyright © 2014 by IOS Press, Inc
ISSN
1305-7707
eISSN
1305-7693
DOI
10.3233/JPI-140432
Publisher site
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Abstract

Acute respiratory tract infection (ARTI) is a leading cause of morbidity and mortality in children worldwide including Sri Lanka. This study was undertaken to determine the viral causes and clinical manifestations of ARTI in pre-school children (Age ⩽ 3 years) from the Kegalle area of the Sabaragamuwa Province of Sri Lanka. Nasopharyngeal aspirates (NPAs) from 98 children ⩽ 3 years presenting with ARTI were tested by indirect (screening) and direct (typing) immunofluorescence assay for the presence of respiratory syncytial virus (RSV), influenza A and B, parainfluenza viruses 1, 2 and 3 and adenoviruses. A respiratory virus was detected in 32.3% of cases: RSV 90%, parainfluenza type 2 virus 6% and influenza virus 4%. Detection of RSV was associated with severe cases of bronchiolitis requiring hospitalization. These findings show the importance of viral pathogens in ARTI in pre-school children in Sri Lanka and highlight the diversity of viral pathogens detected in this age group.

Journal

Journal of Pediatric Infectious Diseases – IOS Press

Published: Jan 1, 2014

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