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Protein oxidation in mild essential hypertension

Protein oxidation in mild essential hypertension Clinical Hemorheology and Microcirculation 47 (2011) 1–3 DOI 10.3233/CH-2011-1423 IOS Press Dipartimento di Medicina Interna, Malattie Cardiovaslari e Nefrourologiche, iversit` di Palermo, a Italy An intensified oxidative stress has been associated with aging and many disease, including essential hypertension (EH) [6, 11, 16]. In EH an increased level of reactive oxygen and nitrogen species (RONS) may impair the bioavailability of nitric oxide (NO), by inducing its accelerated transformation in peroxynitrite [4]. Beside this, many other pathophysiological processes in EH may be influenced by RONS, nsidering their harmful effects on the structural and fctional properties of lipids, proteins and nucleic acids. Some points need to be further investigated, such as the relationship between oxidative stress and the degree of hypertension, and identification of the most useful marker of enhanced oxidative stress in this clinical ndition. In EH several papers showed an increase in lipid peroxidation [1, 7, 13]; this datum was also present in juvenile essential hypertension [17] and in newly diagnosed hypertensives [12]. In other reports, however, normal levels of lipid peroxidation were observed [5, 8]. Fewer papers [3, 7, 10, 14] have examined protein oxidation in EH up to now. Among the indicators of protein oxidation, the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Hemorheology and Microcirculation IOS Press

Protein oxidation in mild essential hypertension

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Publisher
IOS Press
Copyright
Copyright © 2012 by IOS Press, Inc
ISSN
1386-0291
eISSN
1875-8622
DOI
10.3233/CH-2011-1423
pmid
22240348
Publisher site
See Article on Publisher Site

Abstract

Clinical Hemorheology and Microcirculation 47 (2011) 1–3 DOI 10.3233/CH-2011-1423 IOS Press Dipartimento di Medicina Interna, Malattie Cardiovaslari e Nefrourologiche, iversit` di Palermo, a Italy An intensified oxidative stress has been associated with aging and many disease, including essential hypertension (EH) [6, 11, 16]. In EH an increased level of reactive oxygen and nitrogen species (RONS) may impair the bioavailability of nitric oxide (NO), by inducing its accelerated transformation in peroxynitrite [4]. Beside this, many other pathophysiological processes in EH may be influenced by RONS, nsidering their harmful effects on the structural and fctional properties of lipids, proteins and nucleic acids. Some points need to be further investigated, such as the relationship between oxidative stress and the degree of hypertension, and identification of the most useful marker of enhanced oxidative stress in this clinical ndition. In EH several papers showed an increase in lipid peroxidation [1, 7, 13]; this datum was also present in juvenile essential hypertension [17] and in newly diagnosed hypertensives [12]. In other reports, however, normal levels of lipid peroxidation were observed [5, 8]. Fewer papers [3, 7, 10, 14] have examined protein oxidation in EH up to now. Among the indicators of protein oxidation, the

Journal

Clinical Hemorheology and MicrocirculationIOS Press

Published: Jan 1, 2012

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