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Clinical Hemorheology and Microcirculation 47 (2011) 1â3 DOI 10.3233/CH-2011-1423 IOS Press Dipartimento di Medicina Interna, Malattie Cardiovaslari e Nefrourologiche, iversit` di Palermo, a Italy An intensiï¬ed oxidative stress has been associated with aging and many disease, including essential hypertension (EH) [6, 11, 16]. In EH an increased level of reactive oxygen and nitrogen species (RONS) may impair the bioavailability of nitric oxide (NO), by inducing its accelerated transformation in peroxynitrite [4]. Beside this, many other pathophysiological processes in EH may be inï¬uenced by RONS, nsidering their harmful effects on the structural and fctional properties of lipids, proteins and nucleic acids. Some points need to be further investigated, such as the relationship between oxidative stress and the degree of hypertension, and identiï¬cation of the most useful marker of enhanced oxidative stress in this clinical ndition. In EH several papers showed an increase in lipid peroxidation [1, 7, 13]; this datum was also present in juvenile essential hypertension [17] and in newly diagnosed hypertensives [12]. In other reports, however, normal levels of lipid peroxidation were observed [5, 8]. Fewer papers [3, 7, 10, 14] have examined protein oxidation in EH up to now. Among the indicators of protein oxidation, the
Clinical Hemorheology and Microcirculation – IOS Press
Published: Jan 1, 2012
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