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Osmotic deformability of erythrocytes at various shear stresses

Osmotic deformability of erythrocytes at various shear stresses Red blood cell (RBC) deformability is greatly affected by the osmolality, and maximum deformability, which is determined as maximal elongation index (EI max ), is usually observed in isotonic conditions at high shear stresses (>20 Pa). Therefore, we examined osmotic RBC deformability over a range of shear stresses (0.5–20 Pa). We found that the RBC deformability at low shear stresses (1–3 Pa) was maximum in hypotonic conditions (225–250 mOsm/kg H 2 O), which is slightly lower than the normal range of osmolality in plasma (290–310 mOsm/kg H 2 O). The phenomenon that O max (the osmolality at EI max ) is dependent on applied shear stress could play an important role in microcirculation in which osmolality varies widely. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Hemorheology and Microcirculation IOS Press

Osmotic deformability of erythrocytes at various shear stresses

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References (43)

Publisher
IOS Press
Copyright
Copyright © 2015 by IOS Press, Inc
ISSN
1386-0291
eISSN
1875-8622
DOI
10.3233/CH-131761
pmid
24004549
Publisher site
See Article on Publisher Site

Abstract

Red blood cell (RBC) deformability is greatly affected by the osmolality, and maximum deformability, which is determined as maximal elongation index (EI max ), is usually observed in isotonic conditions at high shear stresses (>20 Pa). Therefore, we examined osmotic RBC deformability over a range of shear stresses (0.5–20 Pa). We found that the RBC deformability at low shear stresses (1–3 Pa) was maximum in hypotonic conditions (225–250 mOsm/kg H 2 O), which is slightly lower than the normal range of osmolality in plasma (290–310 mOsm/kg H 2 O). The phenomenon that O max (the osmolality at EI max ) is dependent on applied shear stress could play an important role in microcirculation in which osmolality varies widely.

Journal

Clinical Hemorheology and MicrocirculationIOS Press

Published: Jan 1, 2015

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