The molecular and crystal structure of the alkaloid haloxine
Abstract
<h2>Acta Crystallographica Section B</h2><h3>Structural Crystallography and Crystal Chemistry</h3><h3>0567-7408</h3> <h2>research papers</h2> Volume 24 Part 2 Pages 252-258 February 1968 <h2>The molecular and crystal structure of the alkaloid haloxine</h2> B. Nilsson 252 Acta Cryst. (1968). B24, 252 The Molecular and Crystal Structure of the Alkaloid Haloxine BY Bo NILSSON Crystallography Group, University of G6teborg, G6teborg, Sweden (Received 31 January 1967 and in revised form 23 June 1967) A new alkaloid, haloxine, has been isolated from Haloxylon salicornicum (Chenopodiaceae). Although it is a natural product with asymmetric carbon atoms, its hydrobromide C16H27N20+Br- crystallizes in the centrosymmetric space group PT demanding a racemate. Its structure has been solved by single- crystal heavy-atom techniques. The oxygen and nitrogen atoms were differentiated from the carbon atoms by least-squares refinement of the isotropic temperature factors. Introduction The alkaloid content of Haloxylon salicornicum (Moq.- Tand.) Boiss. (Chenopodiaceae) has previously been studied by Sandberg, Svanquist, Odberg & Sonmark (1960). A number of bases were detected and the main alkaloid, haloxine, was isolated as the hydrochloride (C16H2702N+ C1-, m.p. 193.5-196.0 °C). Chemical work established the quantitative formula and the presence of amide and amine nitrogen and of a keto oxygen atom (Michel, Sandberg, Haglid & Norin, 1967). As