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that TGF -β/Smad signaling pathway plays a crucial role in renal fibrosis . Therefore, targeted inhibition of TGF -β/Smad signaling pathway can be used as a potential therapeutic measure for tubulointerstitial ...
the critical role of TGF -β and its downstream molecules in the progression of fibrosis and cancers, therapeutics targeting TGF -β signaling appears to be a promising strategy. However, due to potential systemic ...
review the complex mechanisms involved in TGF -β-mediated vascular fibrosis that includes the Smad signaling pathway, activation of protein kinases and crosstalk between these pathways. TGF -β blockade ...
by intestinal fibrosis , which is a problem that needs to be resolved. TGF -β signaling is known to act as a key regulator of intestinal fibrosis , and its modulation could be an excellent candidate for fibrosis ...
Tissue fibrosis is a key factor leading to disability and death worldwide; however, thus far, there are no approved treatments for fibrosis . Transforming growth factor ( TGF )-β is a major pro-fibrotic ...
as a central pathway of pulmonary fibrosis , and the suppression of TGF -β1 or the TGF -β1-regulated signaling pathway may thus offer potential antifibrotic therapies. JAK-STAT is a downstream signaling pathway ...
, and/or angiogenesis. In this review article, we have tried to dive deep into the mechanism of action of TGF ‐β in inflammation, fibrosis , and carcinogenesis. As TGF ‐β and its downstream signaling mechanism ...
. YAP/TAZ integrates diverse cell signaling events and interacts with signaling pathways related to fibrosis , including the TGF -β/SMAD pathway. We investigated the expression of YAP/TAZ following vocal ...
Fibrosis is the ‘end‐point’ of a tissues response to chronic or prolonged injury, is often associated with inflammation and activation of the immune system, and can occur in almost any organ ...
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