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that time-restricted GDNF expression (1 month) using an immune-evasive doxycycline-inducible gene switch attenuated local axon entrapment in avulsed reimplanted ventral spinal roots, was sufficient to promote ...
to secrete trophic factors to protect striatal neurons from neurodegeneration.Another area in which human neural cell transplantation has already been used is in spinal cord injury. In posttraumatic ...
phase 2 testing early in 2012, said Harrison. Novel treatment approaches Novel treatment approaches One new approach to treating pain involves using targeted gene therapy technology to block pain signals ...
) and mice with both transgenes present (TDP-43M337V/M337V/Oxr1Prnp/−). Using lysates from the spinal cord , we confirmed that that TDP-43M337V/M337V express the Ypet-tagged human TDP-43M337V protein at levels ...
heterogeneously within a group of other cells. The capacity to specifically generate very targeted expression results in the ability to use light to modulate activity in a very select population of neurons (Figure ...
Study” (RISCIS) to assess the effects of riluzole using the American Spinal Injury Association (ASIA) Impairment Scale (AIS), Spinal Cord Independence Measure, and brief pain inventory outcomes [31 ...
, EGR2, and HOXB2), and also spinal cord (HOXB6) markers (Fig. 3E), but not midbrain markers (PAX2 and EN1) in our CB-iNSCs (data not shown). Interestingly, we observed the same gene expression profile ...
and spinal cords were removed and processed for analysis. All animal experiments were approved by the University of California, Irvine Institutional Animal Care and Use Committee. Cell Culture, Transplantation ...
the spatiotemporal distribution of Gal1 in rats with SCI. Compared with non- expression of Gal1 in intact rat, the expression of Gal1 was significantly upregulated in spinal cords after SCI. Gal1 was expressed in ∼40 ...
in molecular diagnosis with novel gene transfer techniques. Genes may be transferred directly to neural tissue using viral vectors or by physical methods, or indirectly by injection of cell vehicles that express ...
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