Access the full text.
Sign up today, get unlimited access with DeepDyve Pro!
as pseudo substrate inhibi- tors of butyrylcholinesterase . These inhibitions discriminate enantiomers of the inhibitors and therefore show stereoselectivity for the enzyme. For inhibitions by (R)-(+)- and (S ...
, protecting the cholinergic system against OPs. The stereoselectivity of BChE is an important parameter for its efficiency at scavenging the most toxic OPs enantiomer for AChE. Crystals of BChE inhibited ...
of inhibition (Ka = 3.3 μM) indicated that binding to the catalytic site of BChE occurred. From the ratio of the kcat/KM values of both enantiomers an enantiomeric excess of 95% was calculated for N‐methyl ...
conversion of bambuterol into terbutaline involves hydrolysis by butyrylcholinesterase (EC 3.1.1.8), we studied the reaction of enantiomers with eight human BChE variants. Both enantiomers inhibited all ...
the concentration that causes 50% of enzyme inhibition (IC50) of the three isoforms of methamidophos. (−)‐Methamidophos showed an IC50 approximately three times larger than the (+)‐ enantiomer for plasma BChE of hens ...
determined the inhibition potency of racemate and enantiomers of fenoterol as a resorcinol derivative, isoetharine and epinephrine as catechol derivatives and salbutamol and salmeterol as saligenin derivatives ...
Abstract: The naturally occurring enantiomer of cocaine, (–)‐cocaine, has been previously labeled with 11C on the N‐methyl group and used in conjunction with positron emission tomography to show ...
)‐ and ( S )‐ enantiomers . Enantiomers of chiral drugs can exhibit stereoselectivity in their interactions with their targets and may have different therapeutic effects. Previous studies have demonstrated ...
of cinchonines and cinchonidines. Furthermore, the in vitro-determined affinity of the studied compounds, their inhibition selectivity as well as stereoselectivity of cholinesterases, were interpreted and defined ...
Abstract The phosphoramidate nerve agent tabun inhibits butyrylcholinesterase (BChE) and acetylcholinesterase by making a covalent bond on the active site serine. The adduct loses an alkyl group ...
Access the full text.
Sign up today, get unlimited access with DeepDyve Pro!