State-wide hospital clinical laboratory plan for measuring cholinesterase activity for individuals suspected of exposure to nerve agent chemical weapons

State-wide hospital clinical laboratory plan for measuring cholinesterase activity for... Background . Hospital laboratories currently lack the capacity to provide emergency determination of cholinesterase activity. Methods . We have developed a hospital-based 3-tiered system to test plasma for butyrylcholinesterase (BChE) activity and whole blood for red cell acetylcholinesterase (AChE) activity using available technology and personnel. Interagency communications, toxidrome definition, and patient triage will be coordinated by the Connecticut Department of Public Health and the Poison Control Center. Data . Initial BChE data documents good precision between institutions (coefficient of variation < 8%). Summary . Laboratory testing of plasma or blood for cholinesterase activity is important in the management of nerve agent exposure and in ruling out disease in those with non-specific symptoms in the setting of a terrorist attack or accidental exposure. Rapid availability of strong hospital-based analytic support in a smoothly functioning network of clinical, public health, and laboratory services will facilitate overall regional response to chemical terrorism or large scale HazMat events. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Toxicology Informa Healthcare

State-wide hospital clinical laboratory plan for measuring cholinesterase activity for individuals suspected of exposure to nerve agent chemical weapons

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State-wide hospital clinical laboratory plan for measuring cholinesterase activity for individuals suspected of exposure to nerve agent chemical weapons

Abstract

Background . Hospital laboratories currently lack the capacity to provide emergency determination of cholinesterase activity. Methods . We have developed a hospital-based 3-tiered system to test plasma for butyrylcholinesterase (BChE) activity and whole blood for red cell acetylcholinesterase (AChE) activity using available technology and personnel. Interagency communications, toxidrome definition, and patient triage will be coordinated by the Connecticut Department of Public Health and the Poison Control Center. Data . Initial BChE data documents good precision between institutions (coefficient of variation < 8%). Summary . Laboratory testing of plasma or blood for cholinesterase activity is important in the management of nerve agent exposure and in ruling out disease in those with non-specific symptoms in the setting of a terrorist attack or accidental exposure. Rapid availability of strong hospital-based analytic support in a smoothly functioning network of clinical, public health, and laboratory services will facilitate overall regional response to chemical terrorism or large scale HazMat events.
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Publisher
Informa Healthcare
Copyright
© 2008 Informa plc
Subject
Cholinesterase
ISSN
1556-3650
D.O.I.
10.1080/15563650701664830
Publisher site
See Article on Publisher Site

Abstract

Background . Hospital laboratories currently lack the capacity to provide emergency determination of cholinesterase activity. Methods . We have developed a hospital-based 3-tiered system to test plasma for butyrylcholinesterase (BChE) activity and whole blood for red cell acetylcholinesterase (AChE) activity using available technology and personnel. Interagency communications, toxidrome definition, and patient triage will be coordinated by the Connecticut Department of Public Health and the Poison Control Center. Data . Initial BChE data documents good precision between institutions (coefficient of variation < 8%). Summary . Laboratory testing of plasma or blood for cholinesterase activity is important in the management of nerve agent exposure and in ruling out disease in those with non-specific symptoms in the setting of a terrorist attack or accidental exposure. Rapid availability of strong hospital-based analytic support in a smoothly functioning network of clinical, public health, and laboratory services will facilitate overall regional response to chemical terrorism or large scale HazMat events.

Journal

Clinical ToxicologyInforma Healthcare

Published: Feb 1, 2008

Keywords: Cholinesterase, Pseudobutyrylcholinesterase, Acetylcholinesterase, Nerve agent, Sarin, Chemical terrorism

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