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the formation and repair of UV damage occur in the context of chromatin , in which genomic DNA is packaged with histones into nucleosomes and higher order chromatin structures . Here, we review how chromatin ...
range of DNA damage. The aim of the work was to investigate whether the efficiency of the repair of photoproducts induced by UV-light is affected by the circadian phase at which irradiation occurred. NER ...
Summary DNA repair and protection processes impose arduous demands upon cellular systems. The high‐fidelity recombinational repair pathway entails a rapid genome‐wide search for sequence homology ...
October 4, 2010 ABSTRACT (6-4) photoproduct [(6-4)PP]. The nucleotide excision repair (NER) pathway is responsible for repairing DNA Chromatin structure is known to be a barrier to DNA damage caused by UV ...
in chromatin . Here, we will discuss the roles of different histone modifications and the corresponding modifying enzymes in DNA excision repair , highlighting the role of yeast as a model organism for many ...
, and find that most of it is associated with this structure where the transcription and repair factories are also located. The lack of NER factors may be due to the special chromatin organization in nucleoli ...
representation of the unstructured linker. Top panels represent top views and bottom panels represent side views. Histone variants modulate DNA repair , with their structural alterations playing a key role ...
). In eukaryotic cells, where DNA is packaged in chromatin , the DNA structure of T-tracts is unknown. Here we have used in vivo UV photofootprinting and DNA repair by photolyase to investigate the structure ...
restriction, we will not cover replication-associated DNA repair , the role of chromatin for long-range interactions, or the recently emerging role of small RNA in DDR; instead, we focus on defects during ...
(26,27). Studies on repair of UV-induced DNA lesions in yeast minichromosomes showed that both NER and PR are affected by local chromatin structures (7,9,28). Repair by photolyase was more efficient than ...
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