Access the full text.
Sign up today, get unlimited access with DeepDyve Pro!
for muscle-invasive bladder cancer (MIBC), identifying opportunities to refine eligibility, design and end points for neoadjuvant trials in MIBC. Although pathological complete response (pCR) is already being ...
clinical trials of FGFR inhibitors, and resistance patterns. Urothelial cancer, FGFR alterations, FGFR inhibitors, Erdafitinib, Targeted therapy Introduction In the U.S., bladder cancer is the fourth most ...
of distinct molecular mechanisms and similar treatment opportunities between upper tract urothelial carcinoma (UTUC) and urothelial carcinoma of the bladder (UCB) and had important implications for the site ...
for the conflicting results of two closely designed clinical trials . Bladder -sparing approach for stage I-III disease RC is the standard therapy for patients with BCG-unresponsive NMIBC or MIBC. However, quite a few ...
is crucial for improving clinical management of bladder urothelial carcinomas. Methods Tumor grade is defined by pathologic evaluation of tumor cell differentiation, and it often associates with clinical ...
was revealed during these clinical trials : acellular scaffolds allow for spontaneous regeneration of the urothelium but not smooth muscles. Other biomaterials that have been used for urinary bladder ...
the previously noted class of wild-type GISTs and the associated treatment implications in the current era of kinase inhibition, and future clinical trial opportunities . Abstract 9 – Implications of Genomic ...
resulted in increased complexity of clinical trial eligibility criteria and multi-arm study designs . Clinical trial data models that can store this complex information in meaningful, structured annotations ...
) and in bladder cancer (where the role of adjuvant therapy is unclear at present) (4). In the last decade, immune checkpoint inhibitors (ICIs) have revolutionized the treatment and improved survival of metastatic ...
. The ability to efficiently and accurately determine molecular subtype in UC would enable incorporation into clinical trial design and translational research efforts to improve patient selection strategies ...
Access the full text.
Sign up today, get unlimited access with DeepDyve Pro!