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their antigen- binding regions. The results are consistent with the notion that the antigen- binding region is influential through direct autoantibody–glomerular autoantigen interactions in the various models ...
the disease with CTLA4-Fc, significantly suppressed mouse anti-sheep globulin antibody titres in serum, and immunoglobulin and complement deposition in glomeruli . The degree of glomerular necrosis was improved ...
by pressing the minced renal cortexes through sieves of graded sizes. Glomeruli were suspended in Hank's solution containing 25 U/ml of collagenase type II, 0.01 mg/ml of DNase type I (Sigma Chemical Co.) and 1 ...
-like nephritis . Ann Rheum Dis 2007 ; 66 : 1661 – 1668 . Google Scholar Crossref Search ADS PubMed WorldCat 9 Mjelle JE , Rekvig OP, van der Vlag J, Fenton KA. Nephritogenic antibodies bind in glomeruli ...
indicated that IgA deposits are formed not only through classical antigen– antibody interactions , but also by other mechanisms as well. Recent reports revealed that the interaction of IgA with mesangium ...
form in three different ways. Antibodies can bind to exogenous antigens that localize on the subepithelial surface because of their cationic charge and small size (Fig. 2); secondly, antigens ...
to sulphated sugar chains on the ligands. Several studies reported that sulphatide, a sulphated glycolipid, specifically interacts with L-selectin by binding to its sulphated sugar chains [6,7]. Furthermore ...
or to DNA antibody binding . In spite of the fact that anti-DNA antibodies in SLE are important disease markers it seems that only a minority of them is nephritogenic [4]. Hylkema et al. [5] showed that Farr ...
provided direct evidence for the role of activated reactive oxygen species (ROS) in the early stages of experimental IgAN through interaction with the activated renin–angiotensin system (RAS) [12,13 ...
in an amplification loop of the RPGN, independent of the initial antigen- antibody -mediated process that results in the eventual destruction of the glomeruli and progressive kidney failure. At this point, the usual ...
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