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of the Neonatal Intensive Care Unit (NICU) may lead to hair-cell damage and subsequent auditory impairments. In addition, several mitochondrial DNA mutations are known to have been associated with aminoglycoside ...
frequency of all variants was 7.3%. All genetic changes were detected in samples belonged to the haplogroups H, U, T, and J. The presence of several aminoglycoside ototoxicity -related MT-RNR1 gene mutations ...
Mutations in mitochondrial DNA (mtDNA) have been found to be associated with sensorineural hearing loss. We report here a systematic mutational screening of the mitochondrial 12S rRNA gene in 128 ...
–induced ototoxicity . © 1993 Nature Publishing Group http://www.nature.com/naturegenetics article Mitochondrial ribosomal RNA mutation associated with both antibiotic-induced and non syndromic deafness ...
identification of an A1555G mutation in human mitochondrial DNA implicated in aminoglycoside -induced ototoxicity Received: March 5, 1999 / Accepted: June 4, 1999 Abstract This article describes a multiplex allele ...
factor, in addition to aminoglycoside antibiotics, in the phenotypic expression of the non‐syndromic hearing loss associated with the 1555A→G mitochondrial mutation . © 2001 Wiley‐Liss, Inc. INTRODUCTION ...
, aminogly- associated with predisposition to aminoglycoside oto- coside, ototoxicity , HL. toxicity and HL. Mutation screening in this gene has Laryngoscope, 115:640–644, 2005 been recommended before ...
hearing loss, one of which is the A1555G mutation in the 12S ribosomal RNA ( 3 ). Aminoglycosides are potentially ototoxic especially in high doses. Persons with the A1555G mutation of mitochondrial DNA ...
Abstract: Mutations in the mitochondrial DNA (mtDNA) have been shown to be one important cause of deafness. In particular, mutations in the mtDNA have been associated with both syndromic ...
The A1555 G mutation in mitochondrial 12S rRNA has been found to be associated with non-syndromic deafness and aminoglycoside -induced deafness. The sensitivity to the aminoglycoside paromomycin has ...
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