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Objectives Patients with rheumatoid arthritis (RA) have an increased mortality and morbidity due to cardiovascular disease (CVD). In this prospective 5-year follow up of patients with RA, we analysed ...
by colorimetric assay, and signalling pathways were examined by Western blot. The results showed that serum levels of MIF were significantly higher in patients with SSc (n = 47) than in healthy controls (n = 56 ...
Summary Macrophage migration inhibitory factor ( MIF ) is a pleiotropic pro-inflammatory cytokine with many cellular targets in rheumatoid arthritis (RA). MIF has been reported to activate cells via ...
in part, in the pathogenesis of RA. PP-036-24 Elevated serum IL-33 levels in patients with refractory rheumatoid arthritis to anti- TNF therapy Y. Matsuyama Y. Matsuyama Jichi Medical University, Shimotsuke ...
the correlation between serum MIF content and urinary levels of MIF in patients with FGS. We found no significant correlation between the two parameters in the patients (Fig. 6). The data suggest that increased ...
, and induces the production of TNF -α by macrophages [10]. MIF plays an important role in the pathogenesis of inflammatory diseases. The serum and the local expression of MIF are significantly up-regulated ...
strategy in rheumatoid arthritis . K/B×N serum , leukaemia inhibitory factor, mice arthritis model Introduction Cytokines have been implicated strongly in the pathogenesis of rheumatoid arthritis (RA ...
to that of rheumatoid arthritis patients , which appears to facilitate TNF -driven osteo-proliferative changes in AS. In addition, there is considerable interest in the central role of IL-23/IL-17 axis in type 3 immunity ...
) [9], experimental autoimmune myocarditis [10], rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and atherosclerosis [11]. It has been reported that patients with uveitis exhibit prominent ...
diabetic mice or from mice treated with the MIF inhibitors did not contain detectable amounts of either IFN-γ or IL-10 (not shown). In contrast, secretion of the proinflammatory cytokine TNF -α, which ...
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