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Background Alzheimer's disease (AD), the main cause of dementia in the adult population, is characterized by a progressive loss of cognitive function. It is considered that neuroinflammation plays ...
), the development of local inf lammation, metabolic disorders and damage to the blood–brain barrier in two experimental models of Alzheimer’s disease were studied in vivo. The new effects of Aβ in the hippocampal ...
, in Microglial activation is a key feature in Alzheimer’s neuroinflammation in Alzheimer’s disease . disease and is considered to contribute to progressive Copyright © 2007 S . Karger AG, Basel neuronal injury ...
Alzheimer’s disease (AD) is the most common cause of dementia. In recent years, several studies have robustly shown that neuroinflammation plays a crucial role in the pathophysiology of this disease ...
Oxidative stress and neuroinflammation are mainly involved in the pathogenic mechanisms of Alzheimer’s disease (AD). Amyloid-β (Aβ), the main component of senile plaques, is a kind of strong inducer ...
by pro‐inflammatory stimuli including Aβ, lipopolysaccharide, and interleukins. We hypothesized that neuroinflammation is critical for disease progression and selective COX‐1 inhibition, rather than COX‐2 ...
neuropathogenesis. J Neuroimmune Pharmacol (2012) 7:156–164 DOI 10.1007/s11481-011-9331-2 ORIGINAL ARTICLE Chronic IL-1β-Mediated Neuroinflammation Mitigates Amyloid Pathology in a Mouse Model of Alzheimer’s Disease ...
Neuroinflammation is a central feature of Alzheimer’s disease (AD). C-reactive protein (CRP) is a key molecule of the acute phase of inflammation that has been localized in the two characteristic ...
Alzheimer’s disease (AD) is characterized by the presence of neuropathological lesions containing amyloid plaques (APs) and neurofibrillary tangles (NFTs) associated with neuroinflammation ...
investigated how neuroinflammation relates to the localization of tau and TDP-43 pathology, and to the heterogeneity of clinical disease . We used PET in vivo with (i) 11C-PK-11195, a marker of activated ...
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