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PARP , promoted mitophagy and induced cell apoptosis in cardiomyocytes. Poly ( ADP ‐ ribose ) polymerase inhibition suppressed H/R‐ induced mitophagy and cell apoptosis . Parkin knockdown with lentivirus vectors ...
To investigate the role of poly ( ADP - ribose ) polymerase ( PARP ) in the physiological condition of cell growth, we studied the ability of PARP inhibitors to induce apoptosis . Benzamide (BA) and 4-amino ...
cells repair their defective gene via defective homologues recombination (HR) in the presence of enzyme PARP . PARP inhibitors inhibit the enzyme poly ( ADP - ribose ) polymerases ( PARPs ) which lead ...
Paraptosis is mediated by several proteins, poly ( ADP - ribose ) polymerase being one of them. D. discoideum lacks caspases thus providing a better system to dissect out the role of PARP in paraptosis ...
Poly (ADPR) polymerase ( PARP ; EC 2.4.2.30) is a nuclear enzyme, which, when activated by oxygen- and nitrogen-radical- induced DNA strand breaks, transfers ADP ribose units to nuclear proteins ...
Objectives. To investigate the effect of poly ( ADP - ribose ) polymerase 1 ( PARP -1) suppression on CD95/Apo-1 (Fas)- induced apoptosis in fibroblast-like synoviocytes (FLS) from RA patients.Methods ...
the requirement for poly ( ADP - ribose ) polymerase ( PARP )-1 as an upstream regulator of p53 in zinc depletion- induced neuronal apoptosis . First, we found that chemical inhibition or genetic deletion of PARP -1 markedly ...
Poly ( ADP ‐ ribose ) polymerase ( PARP ) is known to be activated under conditions of oxidative stress and/or radiation exposure. The role of this enzyme has been well demonstrated in the streptozotocin ...
of gastric cancer cells and induced the apoptosis by activating Poly ( ADP - ribose ) polymerase 1 ( PARP -1) and caspase-3. Pharmacological inhibition and genetic knockdown with PARP -1 or caspase-3 suppressed DSE2 ...
Poly ( ADP - ribose ) polymerases ( PARPs ) are ADP -ribosylating enzymes and play important roles in a variety of cellular processes. Most small-molecule PARP inhibitors developed to date have been against ...
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