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production of the inflammatory cytokine , interleukin-2 (IL-2). These cytokine delivery circuits can potently enhance CAR T cell infiltration and clearance of immune-excluded tumors (immunocompetent models ...
Adoptive immunotherapy using chimeric antigen-receptor (CAR)- engineered T cells can induce robust antitumor responses against hematologic malignancies. However, its efficacy is not durable ...
thyroiditis. Overall, this study shows that engineered DC-directed enhanced concurrent activation of multiple T cell coinhibitory pathways is an effective way to induce self-antigen specific T cell tolerance ...
with the ability to kill, and helper (CD4+) T ‐ cells , endowed with the dedicated production of cytokines , are needed for clearing cancers and modulating aberrant responses. Controlled manipulation ...
. To further enhance anti-tumor function, we expressed a PD-1-CD28 fusion receptor in TRuC T cells aiming to prevent tumor- induced immune suppression and T cell anergy.MethodsThe activation level of engineered T ...
to induce permanent CAR expression in T cells , which contributes to high production costs and long‐term side effects. Thus, this work aims to develop an in vivo CAR T cell engineering platform to streamline ...
The differentiation of naïve CD4+ T cells into T helper 2 (Th2) cells requires production of the cytokine IL-4 in the local microenvironment. It is evident that naïve/quiescently ...
engineered to express an MSLN-specific TCR (TCR530) alone or with a truncated Fas receptor or a Fas-4-1BB IFP and evaluated for cytokine production and tumor lysis.ResultsRelative to murine T cells expressing ...
to T - cell cytokine production and their proliferation. Dendritic cells express several costimulatory molecules and are believed to be the most potent APCs. Two recombinant poxvirus vectors (replication ...
of tumor cells , induces IP-10 secretion facilitating (CXCR3+) immune cell infiltration, and can prime macrophages to an M1-like phenotype inducing proinflammatory cytokine release. We had previously reported ...
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