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was made (EBVd) from PBMC of the HLA identical donor . For the selection of a mHa specific T cell line, post allo-SCT PBMC from the myeloma patient were used, which was obtained when a clinical GVM ...
inhibit allogeneic dendritic cell -stimulated MLR cultures. Blood 2004 ; 104 : 453 –461 Google Scholar 18 Groux H et al . A CD4 + T - cell subset inhibits antigen - specific T - cell responses and prevents ...
at capturing and presenting antigens to T cells [5–7]. By priming them in vitro with tumour antigens , these ‘professional’ antigen -presenting cells (APCs) may bypass the state of ignorance in which the immune ...
CMV exposure [20]. Recently, it has been shown that there are two distinct types of long-lived NK cells in mice, one being antigen - specific (memory) and the other being cytokine-driven [21 ...
apoptosis of the antigen ‐ specific T cells in vitro and suppressed both delayed‐type hypersensitivity (DTH) and contact hypersensitivity (CH) responses in an antigen ‐ specific manner in syngeneic mice. When non ...
for screening of cDNA expression libraries for identification of cognate antigens . leukaemia/lymphoma/ myeloma , minor HC, T cell receptor (TCR) Introduction Allogeneic stem cell transplantation (allo-SCT ...
the need for antigen priming . Hence, CAR-NK cells with safer cell sources and genetic engineering approaches can solve many of the challenges faced by conventional CAR- T -based therapeutics. INTRODUCTION Over ...
expression of shared antigens detected by cross-reactive cytotoxic T lymphocytes To further evaluate expression of shared antigens by these tumour cell lines, CTLs from a normal HLA-A2-positive donor were ...
complexes are less peptide specific than T - cell recognition of foreign MHC (also termed “degenerate” response) [23]. Another proposition states that tissue- specific antigens are of prime importance to elicit ...
therapy • Buffy-coat DLI • T cells • NK cells • Dendritic cells Immune-target- specific cellular therapy • TSA- primed T cells • TSA-loaded dendritic cells • TSA-transduced dendritic cells • T cells designed ...
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