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Methotrexate (MTX) is used as an effective chemotherapeutic agent against autoimmune diseases and tumors . Oxidative stress and inflammation are involved in the pathogenesis of MTX-induced damage ...
oxidative stress as indicated by increased malondialdehyde level, decreased glutathione content, and superoxide dismutase (SOD) activity. Furthermore, GalN/LPS increased nuclear factor kappa-B activation ...
with TDO-ns significantly attenuated the increases in serum tumor necrosis factor -alpha (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP), immunoglobulin G (IgG), vascular endothelial growth factor ...
), and acetone (ACON). Other toxicants have been shown to induce oxidative stress by macrophage activation with subsequent release of reactive oxygen species and tumor necrosis factor alpha (TNF‐α). Therefore ...
Both obesity and alcohol can cause oxidative stress , cytokine induction, and steatohepatitis. To determine the consequences of their combination, we compared the hepatic effects of moderate ethanol ...
protects against hepatic I/R injury, as indicated by the decreased levels of serum aminotransferase and less parenchymal necrosis and apoptosis. Serum levels of tumor necrosis factor ‐α, interleukin‐6 ...
Although hepatic ischemia‐reperfusion (IR) injury is partially mediated by tumor necrosis factor ‐α (TNF), we recently found that low‐dose TNF before IR is hepatoprotective. We examined the seemingly ...
Recent studies have implicated tumor necrosis factor α (TNF-α) in the acute toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Since TNF-α sensitizes and activates phagocytic cells to agents ...
Fenofibrate PPARa Hepatic ischemia/ serious clinical problem. The reactive oxygen species reperfusion Histopathology Oxidative stress (ROS) and tumor necrosis factor alpha (TNF-a) are important mediators ...
with a significant increase in a fibrotic marker (tissue inhibitor metalloproteinase-1 – TIMP-1), proinflammatory cytokine ( tumor necrosis factor alpha – TNF-α), and oxidative stress parameters (malondialdehyde [MDA ...
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